Fluorine in PDB 8ss3: Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State)

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Binding sites:

The binding sites of Fluorine atom in the Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State) (pdb code 8ss3). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 12 binding sites of Fluorine where determined in the Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State), PDB code: 8ss3:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 12 in the Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1101 b:22.2 occ:1.00 FAF A:ZK11101 0.0 22.2 1.0 CAZ A:ZK11101 1.3 22.2 1.0 FAH A:ZK11101 2.2 22.2 1.0 FAG A:ZK11101 2.2 22.2 1.0 CAS A:ZK11101 2.4 22.2 1.0 OE1 A:GLU705 2.4 58.1 1.0 OE2 A:GLU705 2.9 58.1 1.0 CD A:GLU705 3.0 58.1 1.0 CAJ A:ZK11101 3.2 22.2 1.0 OH A:TYR732 3.2 40.0 1.0 CAR A:ZK11101 3.3 22.2 1.0 CG A:MET708 3.5 63.6 1.0 NAX A:ZK11101 3.6 22.2 1.0 CAM A:ZK11101 3.8 22.2 1.0 SD A:MET708 4.1 63.6 1.0 OG1 A:THR707 4.3 55.7 1.0 CG A:GLU705 4.3 58.1 1.0 CE2 A:TYR405 4.4 49.5 1.0 CZ A:TYR732 4.4 40.0 1.0 CAV A:ZK11101 4.4 22.2 1.0 CAI A:ZK11101 4.5 22.2 1.0 CAN A:ZK11101 4.6 22.2 1.0 CB A:PRO478 4.8 40.2 1.0 OH A:TYR405 4.8 49.5 1.0 CB A:GLU705 4.9 58.1 1.0 CB A:MET708 4.9 63.6 1.0 CAW A:ZK11101 5.0 22.2 1.0 CZ A:TYR405 5.0 49.5 1.0

Fluorine binding site 2 out of 12 in the Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1101 b:22.2 occ:1.00 FAG A:ZK11101 0.0 22.2 1.0 CAZ A:ZK11101 1.4 22.2 1.0 FAF A:ZK11101 2.2 22.2 1.0 FAH A:ZK11101 2.2 22.2 1.0 CAS A:ZK11101 2.3 22.2 1.0 CAJ A:ZK11101 2.6 22.2 1.0 CB A:PRO478 3.2 40.2 1.0 CG A:PRO478 3.4 40.2 1.0 OH A:TYR450 3.4 59.0 1.0 CAR A:ZK11101 3.6 22.2 1.0 OH A:TYR732 3.8 40.0 1.0 CE2 A:TYR405 4.0 49.5 1.0 CAV A:ZK11101 4.0 22.2 1.0 CG A:GLU402 4.1 61.3 1.0 CD2 A:TYR405 4.2 49.5 1.0 CZ A:TYR450 4.2 59.0 1.0 NAX A:ZK11101 4.3 22.2 1.0 OE1 A:GLU705 4.4 58.1 1.0 CD A:PRO478 4.5 40.2 1.0 CE1 A:TYR450 4.5 59.0 1.0 OE2 A:GLU705 4.5 58.1 1.0 CZ A:TYR732 4.5 40.0 1.0 O A:PRO478 4.6 40.2 1.0 CAI A:ZK11101 4.7 22.2 1.0 CA A:PRO478 4.7 40.2 1.0 CZ A:TYR405 4.8 49.5 1.0 NAP A:ZK11101 4.8 22.2 1.0 CB A:GLU402 4.8 61.3 1.0 CAW A:ZK11101 4.8 22.2 1.0 CAN A:ZK11101 4.9 22.2 1.0 CD A:GLU705 4.9 58.1 1.0

Fluorine binding site 3 out of 12 in the Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1101 b:22.2 occ:1.00 FAH A:ZK11101 0.0 22.2 1.0 CAZ A:ZK11101 1.3 22.2 1.0 FAF A:ZK11101 2.2 22.2 1.0 FAG A:ZK11101 2.2 22.2 1.0 CAS A:ZK11101 2.4 22.2 1.0 NAX A:ZK11101 2.9 22.2 1.0 CAR A:ZK11101 2.9 22.2 1.0 CAN A:ZK11101 3.1 22.2 1.0 CG A:GLU402 3.2 61.3 1.0 CAJ A:ZK11101 3.6 22.2 1.0 CAM A:ZK11101 3.6 22.2 1.0 SD A:MET708 3.6 63.6 1.0 CD A:GLU402 3.7 61.3 1.0 OH A:TYR450 3.7 59.0 1.0 CG A:MET708 3.8 63.6 1.0 OE2 A:GLU402 3.8 61.3 1.0 OE1 A:GLU705 4.1 58.1 1.0 CAI A:ZK11101 4.3 22.2 1.0 CAL A:ZK11101 4.4 22.2 1.0 CB A:GLU402 4.4 61.3 1.0 OE1 A:GLU402 4.6 61.3 1.0 CE A:MET708 4.6 63.6 1.0 CAV A:ZK11101 4.7 22.2 1.0 CAK A:ZK11101 4.8 22.2 1.0 CE2 A:TYR405 4.8 49.5 1.0 CZ A:TYR450 4.8 59.0 1.0 CD A:GLU705 4.9 58.1 1.0

Fluorine binding site 4 out of 12 in the Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State) within 5.0Å range: probe atom residue distance (Å) B Occ B:F1102 b:7.5 occ:1.00 FAF B:ZK11102 0.0 7.5 1.0 CAZ B:ZK11102 1.4 7.5 1.0 FAG B:ZK11102 2.2 7.5 1.0 FAH B:ZK11102 2.2 7.5 1.0 CAS B:ZK11102 2.4 7.5 1.0 OH B:TYR732 2.9 43.6 1.0 CAR B:ZK11102 3.2 7.5 1.0 CAJ B:ZK11102 3.2 7.5 1.0 CAM B:ZK11102 3.4 7.5 1.0 NAX B:ZK11102 3.4 7.5 1.0 CG B:MET708 3.6 63.3 1.0 OE1 B:GLU705 3.6 56.1 1.0 OG1 B:THR707 4.0 56.5 1.0 CZ B:TYR732 4.1 43.6 1.0 CAK B:ZK11102 4.2 7.5 1.0 CAI B:ZK11102 4.4 7.5 1.0 CAV B:ZK11102 4.5 7.5 1.0 CAN B:ZK11102 4.5 7.5 1.0 CE2 B:TYR732 4.6 43.6 1.0 SD B:MET708 4.6 63.3 1.0 CD B:GLU705 4.7 56.1 1.0 CB B:MET708 4.7 63.3 1.0 CB B:GLU705 4.9 56.1 1.0 CAW B:ZK11102 4.9 7.5 1.0

Fluorine binding site 5 out of 12 in the Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State) within 5.0Å range: probe atom residue distance (Å) B Occ B:F1102 b:7.5 occ:1.00 FAG B:ZK11102 0.0 7.5 1.0 CAZ B:ZK11102 1.4 7.5 1.0 FAH B:ZK11102 2.2 7.5 1.0 FAF B:ZK11102 2.2 7.5 1.0 CAS B:ZK11102 2.3 7.5 1.0 CAJ B:ZK11102 2.6 7.5 1.0 OH B:TYR732 3.4 43.6 1.0 CB B:PRO478 3.4 46.5 1.0 CG B:PRO478 3.6 46.5 1.0 CAR B:ZK11102 3.6 7.5 1.0 CZ B:TYR732 3.9 43.6 1.0 CAV B:ZK11102 4.0 7.5 1.0 OH B:TYR450 4.0 66.3 1.0 CE2 B:TYR732 4.1 43.6 1.0 CE2 B:TYR405 4.2 60.3 1.0 NAX B:ZK11102 4.3 7.5 1.0 O B:PRO478 4.3 46.5 1.0 CG B:GLU402 4.4 65.6 1.0 CD2 B:TYR405 4.5 60.3 1.0 CZ B:TYR450 4.6 66.3 1.0 CE1 B:TYR450 4.7 66.3 1.0 CAI B:ZK11102 4.7 7.5 1.0 NAP B:ZK11102 4.7 7.5 1.0 CA B:PRO478 4.8 46.5 1.0 CAW B:ZK11102 4.8 7.5 1.0 CE1 B:TYR732 4.9 43.6 1.0 CAM B:ZK11102 5.0 7.5 1.0 CG B:MET708 5.0 63.3 1.0

Fluorine binding site 6 out of 12 in the Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State) within 5.0Å range: probe atom residue distance (Å) B Occ B:F1102 b:7.5 occ:1.00 FAH B:ZK11102 0.0 7.5 1.0 CAZ B:ZK11102 1.4 7.5 1.0 FAG B:ZK11102 2.2 7.5 1.0 FAF B:ZK11102 2.2 7.5 1.0 CAS B:ZK11102 2.4 7.5 1.0 NAX B:ZK11102 2.9 7.5 1.0 CAR B:ZK11102 2.9 7.5 1.0 CAN B:ZK11102 3.2 7.5 1.0 CG B:GLU402 3.3 65.6 1.0 CAJ B:ZK11102 3.5 7.5 1.0 CAM B:ZK11102 3.5 7.5 1.0 OH B:TYR450 3.6 66.3 1.0 CAL B:ZK11102 3.7 7.5 1.0 CD B:GLU402 3.8 65.6 1.0 CG B:MET708 3.8 63.3 1.0 OE2 B:GLU402 3.9 65.6 1.0 CAK B:ZK11102 4.0 7.5 1.0 CAI B:ZK11102 4.2 7.5 1.0 SD B:MET708 4.3 63.3 1.0 CB B:GLU402 4.5 65.6 1.0 OAQ B:ZK11102 4.5 7.5 1.0 OE1 B:GLU402 4.6 65.6 1.0 CZ B:TYR450 4.6 66.3 1.0 CAV B:ZK11102 4.7 7.5 1.0 OH B:TYR732 4.8 43.6 1.0 CAW B:ZK11102 5.0 7.5 1.0

Fluorine binding site 7 out of 12 in the Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State) within 5.0Å range: probe atom residue distance (Å) B Occ C:F1101 b:21.8 occ:1.00 FAF C:ZK11101 0.0 21.8 1.0 CAZ C:ZK11101 1.3 21.8 1.0 FAH C:ZK11101 2.2 21.8 1.0 FAG C:ZK11101 2.2 21.8 1.0 CAS C:ZK11101 2.4 21.8 1.0 OE1 C:GLU705 2.4 51.0 1.0 OE2 C:GLU705 2.9 51.0 1.0 CD C:GLU705 3.0 51.0 1.0 CAJ C:ZK11101 3.1 21.8 1.0 OH C:TYR732 3.2 33.6 1.0 CAR C:ZK11101 3.3 21.8 1.0 CG C:MET708 3.6 56.1 1.0 NAX C:ZK11101 3.6 21.8 1.0 CAM C:ZK11101 3.8 21.8 1.0 SD C:MET708 4.1 56.1 1.0 OG1 C:THR707 4.3 49.0 1.0 CG C:GLU705 4.3 51.0 1.0 CE2 C:TYR405 4.4 43.3 1.0 CZ C:TYR732 4.4 33.6 1.0 CAV C:ZK11101 4.4 21.8 1.0 CAI C:ZK11101 4.5 21.8 1.0 CAN C:ZK11101 4.6 21.8 1.0 CB C:PRO478 4.8 33.4 1.0 OH C:TYR405 4.8 43.3 1.0 CB C:GLU705 4.9 51.0 1.0 CB C:MET708 4.9 56.1 1.0 CAW C:ZK11101 4.9 21.8 1.0 CZ C:TYR405 5.0 43.3 1.0

Fluorine binding site 8 out of 12 in the Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State) within 5.0Å range: probe atom residue distance (Å) B Occ C:F1101 b:21.8 occ:1.00 FAG C:ZK11101 0.0 21.8 1.0 CAZ C:ZK11101 1.4 21.8 1.0 FAF C:ZK11101 2.2 21.8 1.0 FAH C:ZK11101 2.2 21.8 1.0 CAS C:ZK11101 2.3 21.8 1.0 CAJ C:ZK11101 2.6 21.8 1.0 CB C:PRO478 3.3 33.4 1.0 CG C:PRO478 3.4 33.4 1.0 OH C:TYR450 3.4 51.2 1.0 CAR C:ZK11101 3.6 21.8 1.0 OH C:TYR732 3.9 33.6 1.0 CAV C:ZK11101 4.0 21.8 1.0 CE2 C:TYR405 4.0 43.3 1.0 CG C:GLU402 4.1 54.6 1.0 CD2 C:TYR405 4.2 43.3 1.0 CZ C:TYR450 4.2 51.2 1.0 NAX C:ZK11101 4.3 21.8 1.0 CD C:PRO478 4.5 33.4 1.0 OE1 C:GLU705 4.5 51.0 1.0 CE1 C:TYR450 4.5 51.2 1.0 OE2 C:GLU705 4.5 51.0 1.0 CZ C:TYR732 4.6 33.6 1.0 O C:PRO478 4.6 33.4 1.0 CAI C:ZK11101 4.7 21.8 1.0 CB C:GLU402 4.7 54.6 1.0 CA C:PRO478 4.7 33.4 1.0 NAP C:ZK11101 4.8 21.8 1.0 CZ C:TYR405 4.8 43.3 1.0 CAW C:ZK11101 4.8 21.8 1.0 CAN C:ZK11101 4.9 21.8 1.0 CD C:GLU705 4.9 51.0 1.0

Fluorine binding site 9 out of 12 in the Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State) within 5.0Å range: probe atom residue distance (Å) B Occ C:F1101 b:21.8 occ:1.00 FAH C:ZK11101 0.0 21.8 1.0 CAZ C:ZK11101 1.3 21.8 1.0 FAF C:ZK11101 2.2 21.8 1.0 FAG C:ZK11101 2.2 21.8 1.0 CAS C:ZK11101 2.4 21.8 1.0 NAX C:ZK11101 2.8 21.8 1.0 CAR C:ZK11101 2.9 21.8 1.0 CAN C:ZK11101 3.1 21.8 1.0 CG C:GLU402 3.2 54.6 1.0 CAM C:ZK11101 3.5 21.8 1.0 CAJ C:ZK11101 3.6 21.8 1.0 SD C:MET708 3.6 56.1 1.0 CD C:GLU402 3.7 54.6 1.0 OE2 C:GLU402 3.7 54.6 1.0 CG C:MET708 3.7 56.1 1.0 OH C:TYR450 3.7 51.2 1.0 OE1 C:GLU705 4.1 51.0 1.0 CAI C:ZK11101 4.3 21.8 1.0 CAL C:ZK11101 4.4 21.8 1.0 CB C:GLU402 4.4 54.6 1.0 CE C:MET708 4.5 56.1 1.0 OE1 C:GLU402 4.5 54.6 1.0 CAK C:ZK11101 4.7 21.8 1.0 CAV C:ZK11101 4.7 21.8 1.0 CE2 C:TYR405 4.8 43.3 1.0 CZ C:TYR450 4.8 51.2 1.0 CD C:GLU705 4.9 51.0 1.0

Fluorine binding site 10 out of 12 in the Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Structure of Lbd-Tmd of Ampa Receptor GLUA2 in Complex with Auxiliary Subunits Tarp Gamma-5 and Cornichon-2 Bound to Competitive Antagonist Zk and Channel Blocker Spermidine (Closed State) within 5.0Å range: probe atom residue distance (Å) B Occ D:F1102 b:0.0 occ:1.00 FAF D:ZK11102 0.0 0.0 1.0 CAZ D:ZK11102 1.4 0.0 1.0 FAG D:ZK11102 2.2 0.0 1.0 FAH D:ZK11102 2.2 0.0 1.0 CAS D:ZK11102 2.4 0.0 1.0 OH D:TYR732 2.8 50.1 1.0 CAR D:ZK11102 3.2 0.0 1.0 CAJ D:ZK11102 3.2 0.0 1.0 CAM D:ZK11102 3.4 0.0 1.0 NAX D:ZK11102 3.4 0.0 1.0 OE1 D:GLU705 3.5 62.7 1.0 CG D:MET708 3.6 69.7 1.0 OG1 D:THR707 3.9 63.0 1.0 CZ D:TYR732 4.0 50.1 1.0 CAK D:ZK11102 4.2 0.0 1.0 CAI D:ZK11102 4.4 0.0 1.0 CAV D:ZK11102 4.5 0.0 1.0 CAN D:ZK11102 4.5 0.0 1.0 CE2 D:TYR732 4.5 50.1 1.0 CD D:GLU705 4.6 62.7 1.0 SD D:MET708 4.7 69.7 1.0 CB D:MET708 4.7 69.7 1.0 CB D:GLU705 4.7 62.7 1.0 CAW D:ZK11102 4.9 0.0 1.0

S.P.Gangwar, L.Y.Yen, M.V.Yelshanskaya, A.I.Sobolevsky. Modulation of GLUA2-GAMMA5 Synaptic Complex Desensitization, Polyamine Block and Antiepileptic Perampanel Inhibition By Auxiliary Subunit Cornichon-2 Nat.Struct.Mol.Biol. 2023.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-023-01080-X