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Atomistry » Fluorine » PDB 8qow-8str » 8str | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 8qow-8str » 8str » |
Fluorine in PDB 8str: Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Varient in Complex with 5-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl) Ethoxy)-4-Fluorophenoxy)-7-Fluoro-2-Naphthonitrile (JLJ636), A Non- Nucleoside InhibitorEnzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Varient in Complex with 5-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl) Ethoxy)-4-Fluorophenoxy)-7-Fluoro-2-Naphthonitrile (JLJ636), A Non- Nucleoside Inhibitor
All present enzymatic activity of Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Varient in Complex with 5-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl) Ethoxy)-4-Fluorophenoxy)-7-Fluoro-2-Naphthonitrile (JLJ636), A Non- Nucleoside Inhibitor:
2.7.7.49; 2.7.7.7; 3.1.26.13; Protein crystallography data
The structure of Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Varient in Complex with 5-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl) Ethoxy)-4-Fluorophenoxy)-7-Fluoro-2-Naphthonitrile (JLJ636), A Non- Nucleoside Inhibitor, PDB code: 8str
was solved by
K.Hollander,
A.H.Chan,
W.L.Jorgensen,
K.S.Anderson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Varient in Complex with 5-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl) Ethoxy)-4-Fluorophenoxy)-7-Fluoro-2-Naphthonitrile (JLJ636), A Non- Nucleoside Inhibitor
(pdb code 8str). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Varient in Complex with 5-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl) Ethoxy)-4-Fluorophenoxy)-7-Fluoro-2-Naphthonitrile (JLJ636), A Non- Nucleoside Inhibitor, PDB code: 8str: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 8strGo back to Fluorine Binding Sites List in 8str
Fluorine binding site 1 out
of 2 in the Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Varient in Complex with 5-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl) Ethoxy)-4-Fluorophenoxy)-7-Fluoro-2-Naphthonitrile (JLJ636), A Non- Nucleoside Inhibitor
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 8strGo back to Fluorine Binding Sites List in 8str
Fluorine binding site 2 out
of 2 in the Crystal Structure of Hiv-1 Reverse Transcriptase (Y181C) Varient in Complex with 5-(2-(2-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl) Ethoxy)-4-Fluorophenoxy)-7-Fluoro-2-Naphthonitrile (JLJ636), A Non- Nucleoside Inhibitor
Mono view Stereo pair view
Reference:
K.Hollander,
A.H.Chan,
K.M.Frey,
O.Hunker,
J.A.Ippolito,
K.A.Spasov,
Y.J.Yeh,
W.L.Jorgensen,
Y.C.Ho,
K.S.Anderson.
Exploring Novel Hiv-1 Reverse Transcriptase Inhibitors with Drug Resistant Mutants: A Double Mutant Surprise. Protein Sci. E4814 2023.
Page generated: Thu Dec 28 05:07:17 2023
ISSN: ESSN 1469-896X PubMed: 37861472 DOI: 10.1002/PRO.4814 |
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