Fluorine in PDB 8szf: Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs

Other elements in 8szf:

The structure of Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs also contains other interesting chemical elements:

Calcium (Ca) 4 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs (pdb code 8szf). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs, PDB code: 8szf:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in 8szf

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Fluorine binding site 1 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1208

b:57.7
occ:1.00
 F1 A:YP41208 0.0 57.7 1.0
C12 A:YP41208 1.4 54.2 1.0
F2 A:YP41208 2.2 52.4 1.0
F3 A:YP41208 2.2 51.7 1.0
C8 A:YP41208 2.3 51.1 1.0
C7 A:YP41208 2.7 50.1 1.0
CG2 A:ILE777 3.3 52.6 1.0
C9 A:YP41208 3.6 50.5 1.0
CD1 A:ILE777 4.0 51.4 1.0
C6 A:YP41208 4.1 52.5 1.0
CE2 A:YP41208 4.2 46.7 1.0
CG1 A:ILE777 4.2 51.2 1.0
CB A:ILE777 4.4 53.1 1.0
CZ A:YP41208 4.6 49.8 1.0
C10 A:YP41208 4.7 51.7 1.0
CD2 A:YP41208 4.7 51.4 1.0
C11 A:YP41208 4.9 52.7 1.0
SG A:CYS781 4.9 59.8 1.0
CE3 A:TRP818 5.0 45.7 1.0

Fluorine binding site 2 out of 6 in 8szf

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Fluorine binding site 2 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1208

b:52.4
occ:1.00
 F2 A:YP41208 0.0 52.4 1.0
C12 A:YP41208 1.4 54.2 1.0
F1 A:YP41208 2.2 57.7 1.0
F3 A:YP41208 2.2 51.7 1.0
C8 A:YP41208 2.3 51.1 1.0
C7 A:YP41208 3.1 50.1 1.0
C9 A:YP41208 3.2 50.5 1.0
CD1 A:ILE822 4.1 51.7 1.0
CG1 A:ILE822 4.3 51.4 1.0
C6 A:YP41208 4.4 52.5 1.0
C10 A:YP41208 4.4 51.7 1.0
CG2 A:ILE777 4.8 52.6 1.0
C11 A:YP41208 4.9 52.7 1.0

Fluorine binding site 3 out of 6 in 8szf

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Fluorine binding site 3 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1208

b:51.7
occ:1.00
 F3 A:YP41208 0.0 51.7 1.0
C12 A:YP41208 1.4 54.2 1.0
F1 A:YP41208 2.2 57.7 1.0
F2 A:YP41208 2.2 52.4 1.0
C8 A:YP41208 2.4 51.1 1.0
C9 A:YP41208 2.8 50.5 1.0
CB A:TRP818 3.5 45.0 1.0
C7 A:YP41208 3.6 50.1 1.0
O A:TRP818 4.0 50.0 1.0
CE3 A:TRP818 4.0 45.7 1.0
C10 A:YP41208 4.1 51.7 1.0
CG A:TRP818 4.1 46.8 1.0
C A:TRP818 4.1 46.1 1.0
CA A:TRP818 4.3 41.9 1.0
CD2 A:TRP818 4.3 45.7 1.0
CG1 A:ILE822 4.3 51.4 1.0
CD1 A:ILE822 4.6 51.7 1.0
C6 A:YP41208 4.7 52.5 1.0
N A:ILE819 4.8 48.9 1.0
C11 A:YP41208 4.9 52.7 1.0

Fluorine binding site 4 out of 6 in 8szf

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Fluorine binding site 4 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1006

b:61.1
occ:1.00
 F1 B:YP41006 0.0 61.1 1.0
C12 B:YP41006 1.4 60.9 1.0
F3 B:YP41006 2.2 58.3 1.0
F2 B:YP41006 2.2 59.7 1.0
C8 B:YP41006 2.4 59.0 1.0
C9 B:YP41006 2.7 56.0 1.0
CD1 B:LEU770 3.2 63.7 1.0
CG B:LEU770 3.4 64.8 1.0
C7 B:YP41006 3.6 57.2 1.0
CD2 B:LEU770 3.6 62.2 1.0
C10 B:YP41006 4.1 56.2 1.0
C6 B:YP41006 4.7 57.5 1.0
CB B:LEU770 4.9 61.1 1.0
C11 B:YP41006 4.9 56.3 1.0

Fluorine binding site 5 out of 6 in 8szf

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Fluorine binding site 5 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1006

b:59.7
occ:1.00
 F2 B:YP41006 0.0 59.7 1.0
C12 B:YP41006 1.4 60.9 1.0
F3 B:YP41006 2.2 58.3 1.0
F1 B:YP41006 2.2 61.1 1.0
C8 B:YP41006 2.4 59.0 1.0
C7 B:YP41006 2.8 57.2 1.0
C9 B:YP41006 3.6 56.0 1.0
C6 B:YP41006 4.1 57.5 1.0
CD1 B:ILE777 4.3 49.6 1.0
C10 B:YP41006 4.7 56.2 1.0
C11 B:YP41006 4.9 56.3 1.0
CD2 B:LEU770 5.0 62.2 1.0

Fluorine binding site 6 out of 6 in 8szf

Go back to Fluorine Binding Sites List in 8szf
Fluorine binding site 6 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Cryo-Em Structure of Cinacalcet-Bound Active-State Human Calcium- Sensing Receptor Casr in Lipid Nanodiscs within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1006

b:58.3
occ:1.00
 F3 B:YP41006 0.0 58.3 1.0
C12 B:YP41006 1.4 60.9 1.0
F2 B:YP41006 2.2 59.7 1.0
F1 B:YP41006 2.2 61.1 1.0
C8 B:YP41006 2.4 59.0 1.0
C9 B:YP41006 3.2 56.0 1.0
C7 B:YP41006 3.2 57.2 1.0
CG B:LEU770 3.5 64.8 1.0
CD2 B:LEU770 3.7 62.2 1.0
CD2 B:LEU773 3.8 58.5 1.0
CB B:LEU773 3.9 57.7 1.0
O B:LEU770 4.0 66.4 1.0
N B:GLY774 4.0 55.2 1.0
CD1 B:LEU770 4.1 63.7 1.0
CG B:LEU773 4.3 60.0 1.0
CA B:GLY774 4.3 55.3 1.0
C B:LEU773 4.4 60.2 1.0
C10 B:YP41006 4.4 56.2 1.0
C6 B:YP41006 4.4 57.5 1.0
CD1 B:ILE777 4.5 49.6 1.0
CB B:LEU770 4.7 61.1 1.0
CA B:LEU773 4.8 57.7 1.0
C B:LEU770 4.8 65.1 1.0
CA B:LEU770 4.8 60.4 1.0
C11 B:YP41006 4.9 56.3 1.0
O B:LEU773 4.9 62.4 1.0

Reference:

F.He, C.Wu, Y.Gao, G.Skiniotis. Allosteric Modulation and G-Protein Selectivity of the CA2+-Sensing Receptor Nature 2024.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-024-07055-2
Page generated: Sat Aug 3 00:13:13 2024

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