Fluorine in PDB 8szg: Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs

The structure of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs also contains other interesting chemical elements:

Calcium

(Ca)

3 atoms

The binding sites of Fluorine atom in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs (pdb code 8szg). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs, PDB code: 8szg:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:59.0 occ:1.00 F1 A:YP41201 0.0 59.0 1.0 C12 A:YP41201 1.4 59.0 1.0 F2 A:YP41201 2.2 59.0 1.0 F3 A:YP41201 2.2 59.0 1.0 C8 A:YP41201 2.4 59.0 1.0 C7 A:YP41201 2.7 59.0 1.0 C9 A:YP41201 3.6 59.0 1.0 CD1 A:ILE777 3.7 59.6 1.0 CG2 A:ILE777 3.8 59.6 1.0 CG1 A:ILE777 3.9 59.6 1.0 C6 A:YP41201 4.1 59.0 1.0 CE2 A:YP41201 4.2 59.0 1.0 CD2 A:YP41201 4.3 59.0 1.0 CB A:ILE777 4.5 59.6 1.0 C10 A:YP41201 4.7 59.0 1.0 C4 A:YP41201 4.8 59.0 1.0 O A:TRP818 4.8 54.6 1.0 CZ A:YP41201 4.8 59.0 1.0 CE3 A:TRP818 4.9 54.6 1.0 C11 A:YP41201 4.9 59.0 1.0 CG A:YP41201 5.0 59.0 1.0

Fluorine binding site 2 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:59.0 occ:1.00 F2 A:YP41201 0.0 59.0 1.0 C12 A:YP41201 1.4 59.0 1.0 F1 A:YP41201 2.2 59.0 1.0 F3 A:YP41201 2.2 59.0 1.0 C8 A:YP41201 2.4 59.0 1.0 O A:TRP818 2.6 54.6 1.0 C9 A:YP41201 2.8 59.0 1.0 C7 A:YP41201 3.6 59.0 1.0 C A:TRP818 3.6 54.6 1.0 CB A:TRP818 3.6 54.6 1.0 CA A:TRP818 4.1 54.6 1.0 C10 A:YP41201 4.1 59.0 1.0 CD1 A:ILE819 4.2 54.6 1.0 CE3 A:TRP818 4.5 54.6 1.0 CG A:TRP818 4.6 54.6 1.0 N A:ILE819 4.6 54.6 1.0 C6 A:YP41201 4.7 59.0 1.0 CD2 A:TRP818 4.9 54.6 1.0 C11 A:YP41201 4.9 59.0 1.0 CE2 A:YP41201 5.0 59.0 1.0

Fluorine binding site 3 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:59.0 occ:1.00 F3 A:YP41201 0.0 59.0 1.0 C12 A:YP41201 1.4 59.0 1.0 F2 A:YP41201 2.2 59.0 1.0 F1 A:YP41201 2.2 59.0 1.0 C8 A:YP41201 2.4 59.0 1.0 C9 A:YP41201 3.1 59.0 1.0 C7 A:YP41201 3.3 59.0 1.0 O A:TRP818 4.3 54.6 1.0 C10 A:YP41201 4.4 59.0 1.0 C6 A:YP41201 4.5 59.0 1.0 CG2 A:ILE777 4.7 59.6 1.0 C11 A:YP41201 4.9 59.0 1.0 CD1 A:ILE822 4.9 59.0 1.0

Fluorine binding site 4 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ B:F1407 b:67.8 occ:1.00 F1 B:YP41407 0.0 67.8 1.0 C12 B:YP41407 1.4 67.8 1.0 F2 B:YP41407 2.2 67.8 1.0 F3 B:YP41407 2.2 67.8 1.0 C8 B:YP41407 2.4 67.8 1.0 C7 B:YP41407 2.7 67.8 1.0 C9 B:YP41407 3.6 67.8 1.0 C6 B:YP41407 4.1 67.8 1.0 CD2 B:LEU773 4.5 77.0 1.0 C10 B:YP41407 4.7 67.8 1.0 CB B:LEU773 4.9 77.0 1.0 CG B:LEU773 4.9 77.0 1.0 C11 B:YP41407 4.9 67.8 1.0

Fluorine binding site 5 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ B:F1407 b:67.8 occ:1.00 F2 B:YP41407 0.0 67.8 1.0 C12 B:YP41407 1.4 67.8 1.0 F3 B:YP41407 2.2 67.8 1.0 F1 B:YP41407 2.2 67.8 1.0 C8 B:YP41407 2.4 67.8 1.0 C9 B:YP41407 2.8 67.8 1.0 CD2 B:LEU770 3.4 86.0 1.0 C7 B:YP41407 3.5 67.8 1.0 CG B:LEU770 3.6 86.0 1.0 C10 B:YP41407 4.2 67.8 1.0 CB B:LEU770 4.5 86.0 1.0 C6 B:YP41407 4.7 67.8 1.0 CD1 B:LEU770 4.7 86.0 1.0 CD2 B:LEU773 4.8 77.0 1.0 C11 B:YP41407 4.9 67.8 1.0

Fluorine binding site 6 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gq Complex in Lipid Nanodiscs within 5.0Å range: probe atom residue distance (Å) B Occ B:F1407 b:67.8 occ:1.00 F3 B:YP41407 0.0 67.8 1.0 C12 B:YP41407 1.4 67.8 1.0 F2 B:YP41407 2.2 67.8 1.0 F1 B:YP41407 2.2 67.8 1.0 C8 B:YP41407 2.4 67.8 1.0 C9 B:YP41407 3.1 67.8 1.0 C7 B:YP41407 3.3 67.8 1.0 C10 B:YP41407 4.4 67.8 1.0 C6 B:YP41407 4.5 67.8 1.0 C11 B:YP41407 4.9 67.8 1.0 CD2 B:LEU770 4.9 86.0 1.0

F.He, C.Wu, Y.Gao, G.Skiniotis. Allosteric Modulation and G-Protein Selectivity of the CA2+-Sensing Receptor Nature 2024.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-024-07055-2