Fluorine in PDB 8szh: Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs

Other elements in 8szh:

The structure of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs also contains other interesting chemical elements:

Calcium (Ca) 4 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs (pdb code 8szh). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs, PDB code: 8szh:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in 8szh

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Fluorine binding site 1 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F901

b:52.3
occ:1.00
 F1 A:YP4901 0.0 52.3 1.0
C12 A:YP4901 1.4 50.7 1.0
F2 A:YP4901 2.2 51.5 1.0
F3 A:YP4901 2.2 51.9 1.0
C8 A:YP4901 2.4 46.2 1.0
C7 A:YP4901 2.7 48.0 1.0
CG2 A:ILE777 3.3 40.4 1.0
C9 A:YP4901 3.6 43.0 1.0
C6 A:YP4901 4.1 51.1 1.0
CE2 A:YP4901 4.3 46.1 1.0
CG1 A:ILE777 4.4 35.8 1.0
CB A:ILE777 4.5 36.8 1.0
CD1 A:ILE777 4.6 37.1 1.0
CZ A:YP4901 4.6 46.3 1.0
O A:TRP818 4.6 48.8 1.0
C10 A:YP4901 4.7 45.9 1.0
C11 A:YP4901 4.9 48.3 1.0
CD2 A:YP4901 5.0 45.9 1.0

Fluorine binding site 2 out of 6 in 8szh

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Fluorine binding site 2 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F901

b:51.5
occ:1.00
 F2 A:YP4901 0.0 51.5 1.0
C12 A:YP4901 1.4 50.7 1.0
F1 A:YP4901 2.2 52.3 1.0
F3 A:YP4901 2.2 51.9 1.0
C8 A:YP4901 2.4 46.2 1.0
O A:TRP818 2.5 48.8 1.0
C9 A:YP4901 2.8 43.0 1.0
C A:TRP818 3.4 40.9 1.0
C7 A:YP4901 3.6 48.0 1.0
CB A:TRP818 3.8 38.2 1.0
C10 A:YP4901 4.1 45.9 1.0
CA A:TRP818 4.2 38.2 1.0
N A:ILE819 4.3 37.3 1.0
CG1 A:ILE822 4.4 42.0 1.0
CD1 A:ILE822 4.5 43.5 1.0
CA A:ILE819 4.5 36.4 1.0
CE3 A:TRP818 4.6 42.3 1.0
C6 A:YP4901 4.7 51.1 1.0
CG A:TRP818 4.7 40.3 1.0
C11 A:YP4901 4.9 48.3 1.0
CG1 A:ILE819 4.9 35.8 1.0
CD2 A:TRP818 5.0 41.8 1.0

Fluorine binding site 3 out of 6 in 8szh

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Fluorine binding site 3 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F901

b:51.9
occ:1.00
 F3 A:YP4901 0.0 51.9 1.0
C12 A:YP4901 1.4 50.7 1.0
F2 A:YP4901 2.2 51.5 1.0
F1 A:YP4901 2.2 52.3 1.0
C8 A:YP4901 2.4 46.2 1.0
C9 A:YP4901 3.2 43.0 1.0
C7 A:YP4901 3.2 48.0 1.0
CD1 A:ILE822 4.1 43.5 1.0
CG1 A:ILE822 4.2 42.0 1.0
O A:TRP818 4.4 48.8 1.0
C10 A:YP4901 4.4 45.9 1.0
C6 A:YP4901 4.4 51.1 1.0
CG2 A:ILE777 4.6 40.4 1.0
C11 A:YP4901 4.9 48.3 1.0

Fluorine binding site 4 out of 6 in 8szh

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Fluorine binding site 4 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1402

b:52.3
occ:1.00
 F1 B:YP41402 0.0 52.3 1.0
C12 B:YP41402 1.4 53.5 1.0
F2 B:YP41402 2.2 51.8 1.0
F3 B:YP41402 2.2 55.4 1.0
C8 B:YP41402 2.4 49.5 1.0
C7 B:YP41402 2.9 47.6 1.0
C9 B:YP41402 3.5 48.5 1.0
C6 B:YP41402 4.2 50.1 1.0
C18 B:PCW1403 4.4 55.1 1.0
CD1 B:ILE777 4.5 44.0 1.0
CD2 B:LEU770 4.6 62.8 1.0
C10 B:YP41402 4.6 50.2 1.0
CD2 B:LEU773 4.8 49.0 1.0
CG B:LEU773 4.8 48.7 1.0
C11 B:YP41402 4.9 50.8 1.0
C16 B:PCW1403 5.0 52.4 1.0

Fluorine binding site 5 out of 6 in 8szh

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Fluorine binding site 5 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1402

b:51.8
occ:1.00
 F2 B:YP41402 0.0 51.8 1.0
C12 B:YP41402 1.4 53.5 1.0
F1 B:YP41402 2.2 52.3 1.0
F3 B:YP41402 2.2 55.4 1.0
C8 B:YP41402 2.4 49.5 1.0
C9 B:YP41402 2.7 48.5 1.0
C7 B:YP41402 3.6 47.6 1.0
CD2 B:LEU770 3.7 62.8 1.0
CD1 B:LEU770 3.9 63.0 1.0
C10 B:YP41402 4.1 50.2 1.0
CG B:LEU770 4.3 63.2 1.0
C6 B:YP41402 4.8 50.1 1.0
CB B:LEU770 4.8 62.6 1.0
C11 B:YP41402 4.9 50.8 1.0

Fluorine binding site 6 out of 6 in 8szh

Go back to Fluorine Binding Sites List in 8szh
Fluorine binding site 6 out of 6 in the Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Cryo-Em Structure of Cinacalcet-Bound Human Calcium-Sensing Receptor Casr-Gi Complex in Lipid Nanodiscs within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1402

b:55.4
occ:1.00
 F3 B:YP41402 0.0 55.4 1.0
C12 B:YP41402 1.4 53.5 1.0
F2 B:YP41402 2.2 51.8 1.0
F1 B:YP41402 2.2 52.3 1.0
C8 B:YP41402 2.4 49.5 1.0
C7 B:YP41402 3.0 47.6 1.0
C16 B:PCW1403 3.3 52.4 1.0
C9 B:YP41402 3.4 48.5 1.0
C14 B:PCW1403 3.6 52.9 1.0
C17 B:PCW1403 3.6 54.5 1.0
C18 B:PCW1403 3.7 55.1 1.0
C15 B:PCW1403 4.0 52.5 1.0
C6 B:YP41402 4.3 50.1 1.0
C10 B:YP41402 4.6 50.2 1.0
C19 B:PCW1403 4.8 54.5 1.0
C13 B:PCW1403 4.8 54.9 1.0
C11 B:YP41402 4.9 50.8 1.0
C12 B:PCW1403 5.0 56.5 1.0

Reference:

F.He, C.Wu, Y.Gao, G.Skiniotis. Allosteric Modulation and G-Protein Selectivity of the CA2+-Sensing Receptor Nature 2024.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-024-07055-2
Page generated: Sat Aug 3 00:23:02 2024

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