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Fluorine in PDB 8t0l: E. Coli SW2/SNF2 Atpase Rapa Bound to Both Adp-ALF3 and Reconstituted E. Coli Rna Polymerase Post-Termination Complex on Negatively- Supercoiled Dna

Enzymatic activity of E. Coli SW2/SNF2 Atpase Rapa Bound to Both Adp-ALF3 and Reconstituted E. Coli Rna Polymerase Post-Termination Complex on Negatively- Supercoiled Dna

All present enzymatic activity of E. Coli SW2/SNF2 Atpase Rapa Bound to Both Adp-ALF3 and Reconstituted E. Coli Rna Polymerase Post-Termination Complex on Negatively- Supercoiled Dna:
2.7.7.6;

Other elements in 8t0l:

The structure of E. Coli SW2/SNF2 Atpase Rapa Bound to Both Adp-ALF3 and Reconstituted E. Coli Rna Polymerase Post-Termination Complex on Negatively- Supercoiled Dna also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Zinc (Zn) 2 atoms
Aluminium (Al) 1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the E. Coli SW2/SNF2 Atpase Rapa Bound to Both Adp-ALF3 and Reconstituted E. Coli Rna Polymerase Post-Termination Complex on Negatively- Supercoiled Dna (pdb code 8t0l). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the E. Coli SW2/SNF2 Atpase Rapa Bound to Both Adp-ALF3 and Reconstituted E. Coli Rna Polymerase Post-Termination Complex on Negatively- Supercoiled Dna, PDB code: 8t0l:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in 8t0l

Go back to Fluorine Binding Sites List in 8t0l
Fluorine binding site 1 out of 3 in the E. Coli SW2/SNF2 Atpase Rapa Bound to Both Adp-ALF3 and Reconstituted E. Coli Rna Polymerase Post-Termination Complex on Negatively- Supercoiled Dna


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of E. Coli SW2/SNF2 Atpase Rapa Bound to Both Adp-ALF3 and Reconstituted E. Coli Rna Polymerase Post-Termination Complex on Negatively- Supercoiled Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
F:F1001

b:235.8
occ:1.00
F1 F:AF31001 0.0 235.8 1.0
AL F:AF31001 1.6 235.8 1.0
O1B F:ADP1000 2.2 219.6 1.0
NH1 F:ARG599 2.7 228.5 1.0
F3 F:AF31001 2.8 235.8 1.0
F2 F:AF31001 2.8 235.8 1.0
NH2 F:ARG599 3.1 228.5 1.0
PB F:ADP1000 3.1 219.6 1.0
O3A F:ADP1000 3.1 219.6 1.0
CZ F:ARG599 3.3 228.5 1.0
O3B F:ADP1000 3.5 219.6 1.0
CG1 F:VAL179 3.8 230.9 1.0
CA F:GLY569 4.0 225.3 1.0
N F:GLY180 4.3 226.5 1.0
O2B F:ADP1000 4.5 219.6 1.0
OE2 F:GLU281 4.6 233.9 1.0
NE F:ARG599 4.6 228.5 1.0
PA F:ADP1000 4.7 219.6 1.0
O F:GLY569 4.7 225.3 1.0
C F:GLY569 4.8 225.3 1.0
CA F:GLY180 4.9 226.5 1.0
CB F:VAL179 5.0 230.9 1.0
CA F:VAL179 5.0 230.9 1.0

Fluorine binding site 2 out of 3 in 8t0l

Go back to Fluorine Binding Sites List in 8t0l
Fluorine binding site 2 out of 3 in the E. Coli SW2/SNF2 Atpase Rapa Bound to Both Adp-ALF3 and Reconstituted E. Coli Rna Polymerase Post-Termination Complex on Negatively- Supercoiled Dna


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of E. Coli SW2/SNF2 Atpase Rapa Bound to Both Adp-ALF3 and Reconstituted E. Coli Rna Polymerase Post-Termination Complex on Negatively- Supercoiled Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
F:F1001

b:235.8
occ:1.00
F2 F:AF31001 0.0 235.8 1.0
AL F:AF31001 1.6 235.8 1.0
O3B F:ADP1000 2.2 219.6 1.0
F3 F:AF31001 2.8 235.8 1.0
F1 F:AF31001 2.8 235.8 1.0
NZ F:LYS183 3.0 223.8 1.0
PB F:ADP1000 3.1 219.6 1.0
O1B F:ADP1000 3.3 219.6 1.0
OE2 F:GLU281 3.4 233.9 1.0
CE F:LYS183 3.4 223.8 1.0
O3A F:ADP1000 3.5 219.6 1.0
CB F:ALA314 4.1 236.4 1.0
CD F:GLU281 4.5 233.9 1.0
O2B F:ADP1000 4.5 219.6 1.0
O2A F:ADP1000 4.7 219.6 1.0
PA F:ADP1000 4.7 219.6 1.0
OD1 F:ASP280 4.8 227.9 1.0
CD F:LYS183 4.8 223.8 1.0
CA F:ALA314 4.8 236.4 1.0
CB F:LYS183 5.0 223.8 1.0

Fluorine binding site 3 out of 3 in 8t0l

Go back to Fluorine Binding Sites List in 8t0l
Fluorine binding site 3 out of 3 in the E. Coli SW2/SNF2 Atpase Rapa Bound to Both Adp-ALF3 and Reconstituted E. Coli Rna Polymerase Post-Termination Complex on Negatively- Supercoiled Dna


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of E. Coli SW2/SNF2 Atpase Rapa Bound to Both Adp-ALF3 and Reconstituted E. Coli Rna Polymerase Post-Termination Complex on Negatively- Supercoiled Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
F:F1001

b:235.8
occ:1.00
F3 F:AF31001 0.0 235.8 1.0
AL F:AF31001 1.6 235.8 1.0
O3A F:ADP1000 2.2 219.6 1.0
F2 F:AF31001 2.8 235.8 1.0
F1 F:AF31001 2.8 235.8 1.0
O1A F:ADP1000 3.0 219.6 1.0
PA F:ADP1000 3.1 219.6 1.0
PB F:ADP1000 3.2 219.6 1.0
O3B F:ADP1000 3.3 219.6 1.0
O1B F:ADP1000 3.6 219.6 1.0
OG1 F:THR184 3.8 218.7 1.0
O2A F:ADP1000 3.8 219.6 1.0
NH1 F:ARG599 4.2 228.5 1.0
CA F:GLY569 4.3 225.3 1.0
CD1 F:LEU211 4.4 222.0 1.0
O F:GLY569 4.4 225.3 1.0
O5' F:ADP1000 4.4 219.6 1.0
O2B F:ADP1000 4.5 219.6 1.0
OE2 F:GLU281 4.7 233.9 1.0
OD2 F:ASP280 4.7 227.9 1.0
C5' F:ADP1000 4.7 219.6 1.0
C F:GLY569 4.9 225.3 1.0
OD1 F:ASP280 4.9 227.9 1.0
NH2 F:ARG599 5.0 228.5 1.0
CZ F:ARG599 5.0 228.5 1.0

Reference:

J.J.Brewer, K.Inlow, R.A.Mooney, B.Bosch, P.D.B.Olinares, L.P.Marcelino, B.T.Chait, R.Landick, J.Gelles, E.A.Campbell, S.A.Darst. Rapa Opens the Rna Polymerase Clamp to Disrupt Post-Termination Complexes and Prevent Cytotoxic R-Loop Formation. Nat.Struct.Mol.Biol. 2025.
ISSN: ESSN 1545-9985
PubMed: 39779919
DOI: 10.1038/S41594-024-01447-8
Page generated: Wed Jul 16 08:25:50 2025

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