Fluorine in PDB 8t1f: Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047

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>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Fluorine atom in the Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047 (pdb code 8t1f). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 12 binding sites of Fluorine where determined in the Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047, PDB code: 8t1f:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 12 in the Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047 within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:100.4 occ:1.00 F10 A:X7N1201 0.0 100.4 1.0 C9 A:X7N1201 1.3 100.4 1.0 F11 A:X7N1201 2.1 100.4 1.0 F12 A:X7N1201 2.1 100.4 1.0 C8 A:X7N1201 2.4 100.4 1.0 C13 A:X7N1201 3.0 100.4 1.0 C7 A:X7N1201 3.4 100.4 1.0 C14 A:X7N1201 4.3 100.4 1.0 C6 A:X7N1201 4.6 100.4 1.0 C15 A:X7N1201 5.0 100.4 1.0 CD1 A:LEU523 5.0 134.1 1.0

Fluorine binding site 2 out of 12 in the Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047 within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:100.4 occ:1.00 F11 A:X7N1201 0.0 100.4 1.0 C9 A:X7N1201 1.3 100.4 1.0 F10 A:X7N1201 2.1 100.4 1.0 F12 A:X7N1201 2.1 100.4 1.0 C8 A:X7N1201 2.4 100.4 1.0 C7 A:X7N1201 2.7 100.4 1.0 CG2 A:THR520 3.5 129.7 1.0 C13 A:X7N1201 3.6 100.4 1.0 C6 A:X7N1201 4.1 100.4 1.0 CB A:ALA481 4.4 94.2 1.0 O16 A:X7N1201 4.5 100.4 1.0 CB A:THR520 4.5 129.7 1.0 CA A:THR520 4.6 129.7 1.0 C14 A:X7N1201 4.8 100.4 1.0 O A:PHE519 4.9 133.9 1.0 N A:THR520 4.9 129.7 1.0 CZ A:PHE524 4.9 128.1 1.0 C15 A:X7N1201 4.9 100.4 1.0 CE1 A:PHE524 5.0 128.1 1.0

Fluorine binding site 3 out of 12 in the Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047 within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:100.4 occ:1.00 F12 A:X7N1201 0.0 100.4 1.0 C9 A:X7N1201 1.3 100.4 1.0 F11 A:X7N1201 2.1 100.4 1.0 F10 A:X7N1201 2.1 100.4 1.0 C8 A:X7N1201 2.4 100.4 1.0 C13 A:X7N1201 3.0 100.4 1.0 C7 A:X7N1201 3.4 100.4 1.0 C14 A:X7N1201 4.3 100.4 1.0 CB A:ALA481 4.3 94.2 1.0 O A:SER477 4.6 93.6 1.0 C6 A:X7N1201 4.6 100.4 1.0 CG2 A:THR520 4.8 129.7 1.0 CG2 A:ILE516 4.9 133.2 1.0 C15 A:X7N1201 4.9 100.4 1.0

Fluorine binding site 4 out of 12 in the Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1201 b:14.3 occ:1.00 F10 B:X7N1201 0.0 14.3 1.0 C9 B:X7N1201 1.3 14.3 1.0 F11 B:X7N1201 2.1 14.3 1.0 F12 B:X7N1201 2.1 14.3 1.0 C8 B:X7N1201 2.4 14.3 1.0 C7 B:X7N1201 3.1 14.3 1.0 C13 B:X7N1201 3.3 14.3 1.0 CG2 B:THR520 3.7 97.3 1.0 CE2 B:PHE519 4.0 101.7 1.0 CD2 B:PHE519 4.1 101.7 1.0 CD1 B:LEU523 4.1 98.5 1.0 C6 B:X7N1201 4.4 14.3 1.0 C14 B:X7N1201 4.5 14.3 1.0 CB B:THR520 4.9 97.3 1.0 C15 B:X7N1201 5.0 14.3 1.0

Fluorine binding site 5 out of 12 in the Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1201 b:14.3 occ:1.00 F11 B:X7N1201 0.0 14.3 1.0 C9 B:X7N1201 1.3 14.3 1.0 F12 B:X7N1201 2.1 14.3 1.0 F10 B:X7N1201 2.1 14.3 1.0 C8 B:X7N1201 2.3 14.3 1.0 C7 B:X7N1201 2.8 14.3 1.0 CG2 B:THR520 3.3 97.3 1.0 CB B:ALA481 3.4 59.4 1.0 C13 B:X7N1201 3.5 14.3 1.0 O B:SER477 4.1 56.6 1.0 C6 B:X7N1201 4.2 14.3 1.0 CB B:THR520 4.6 97.3 1.0 O16 B:X7N1201 4.6 14.3 1.0 C14 B:X7N1201 4.7 14.3 1.0 CA B:ALA481 4.9 59.4 1.0 C B:SER477 4.9 56.6 1.0 C15 B:X7N1201 4.9 14.3 1.0

Fluorine binding site 6 out of 12 in the Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1201 b:14.3 occ:1.00 F12 B:X7N1201 0.0 14.3 1.0 C9 B:X7N1201 1.3 14.3 1.0 F11 B:X7N1201 2.1 14.3 1.0 F10 B:X7N1201 2.1 14.3 1.0 C8 B:X7N1201 2.4 14.3 1.0 C13 B:X7N1201 2.8 14.3 1.0 C7 B:X7N1201 3.6 14.3 1.0 C14 B:X7N1201 4.1 14.3 1.0 CB B:ALA481 4.6 59.4 1.0 CG2 B:THR520 4.7 97.3 1.0 O B:SER477 4.7 56.6 1.0 C6 B:X7N1201 4.7 14.3 1.0 C15 B:X7N1201 4.9 14.3 1.0

Fluorine binding site 7 out of 12 in the Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047 within 5.0Å range: probe atom residue distance (Å) B Occ C:F1201 b:96.9 occ:1.00 F10 C:X7N1201 0.0 96.9 1.0 C9 C:X7N1201 1.3 96.9 1.0 F11 C:X7N1201 2.1 96.9 1.0 F12 C:X7N1201 2.1 96.9 1.0 C8 C:X7N1201 2.4 96.9 1.0 C13 C:X7N1201 3.0 96.9 1.0 C7 C:X7N1201 3.4 96.9 1.0 C14 C:X7N1201 4.3 96.9 1.0 C6 C:X7N1201 4.6 96.9 1.0 CG2 C:THR520 4.9 133.0 1.0 C15 C:X7N1201 5.0 96.9 1.0

Fluorine binding site 8 out of 12 in the Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047 within 5.0Å range: probe atom residue distance (Å) B Occ C:F1201 b:96.9 occ:1.00 F11 C:X7N1201 0.0 96.9 1.0 C9 C:X7N1201 1.3 96.9 1.0 F12 C:X7N1201 2.1 96.9 1.0 F10 C:X7N1201 2.1 96.9 1.0 C8 C:X7N1201 2.4 96.9 1.0 C7 C:X7N1201 2.7 96.9 1.0 CG2 C:THR520 3.4 133.0 1.0 C13 C:X7N1201 3.6 96.9 1.0 CB C:ALA481 4.0 94.9 1.0 C6 C:X7N1201 4.1 96.9 1.0 CB C:THR520 4.5 133.0 1.0 O16 C:X7N1201 4.5 96.9 1.0 CA C:THR520 4.6 133.0 1.0 C14 C:X7N1201 4.8 96.9 1.0 CZ C:PHE524 4.8 128.7 1.0 CE1 C:PHE524 4.9 128.7 1.0 C15 C:X7N1201 4.9 96.9 1.0

Fluorine binding site 9 out of 12 in the Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047 within 5.0Å range: probe atom residue distance (Å) B Occ C:F1201 b:96.9 occ:1.00 F12 C:X7N1201 0.0 96.9 1.0 C9 C:X7N1201 1.3 96.9 1.0 F11 C:X7N1201 2.1 96.9 1.0 F10 C:X7N1201 2.1 96.9 1.0 C8 C:X7N1201 2.4 96.9 1.0 C13 C:X7N1201 3.0 96.9 1.0 C7 C:X7N1201 3.4 96.9 1.0 CB C:ALA481 4.0 94.9 1.0 O C:SER477 4.2 93.4 1.0 C14 C:X7N1201 4.3 96.9 1.0 C6 C:X7N1201 4.6 96.9 1.0 CG2 C:THR520 4.8 133.0 1.0 CA C:ALA481 4.9 94.9 1.0 C C:SER477 4.9 93.4 1.0 C15 C:X7N1201 4.9 96.9 1.0

Fluorine binding site 10 out of 12 in the Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Cryo-Em Structure of Full-Length Human TRPV4 in Complex with Antagonist Hc-067047 within 5.0Å range: probe atom residue distance (Å) B Occ D:F1201 b:17.2 occ:1.00 F10 D:X7N1201 0.0 17.2 1.0 C9 D:X7N1201 1.3 17.2 1.0 F11 D:X7N1201 2.1 17.2 1.0 F12 D:X7N1201 2.1 17.2 1.0 C8 D:X7N1201 2.4 17.2 1.0 C7 D:X7N1201 3.2 17.2 1.0 C13 D:X7N1201 3.2 17.2 1.0 CG2 D:THR520 3.7 90.4 1.0 CE2 D:PHE519 4.0 95.1 1.0 CD2 D:PHE519 4.1 95.1 1.0 CD1 D:LEU523 4.3 92.9 1.0 C6 D:X7N1201 4.4 17.2 1.0 C14 D:X7N1201 4.5 17.2 1.0 CB D:THR520 4.9 90.4 1.0 C15 D:X7N1201 5.0 17.2 1.0

K.D.Nadezhdin, I.A.Talyzina, A.Parthasarathy, A.Neuberger, D.X.Zhang, A.I.Sobolevsky. Structure of Human TRPV4 in Complex with Gtpase Rhoa. Nat Commun V. 14 3733 2023.
ISSN: ESSN 2041-1723
PubMed: 37353478
DOI: 10.1038/S41467-023-39346-Z