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Atomistry » Fluorine » PDB 8smc-8t4v » 8t4p » |
Fluorine in PDB 8t4p: Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and Di-Glutamate AGF347 InhibitorEnzymatic activity of Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and Di-Glutamate AGF347 Inhibitor
All present enzymatic activity of Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and Di-Glutamate AGF347 Inhibitor:
2.1.2.1; Protein crystallography data
The structure of Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and Di-Glutamate AGF347 Inhibitor, PDB code: 8t4p
was solved by
J.M.Katinas,
C.E.Dann Iii,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and Di-Glutamate AGF347 Inhibitor
(pdb code 8t4p). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and Di-Glutamate AGF347 Inhibitor, PDB code: 8t4p: Fluorine binding site 1 out of 1 in 8t4pGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and Di-Glutamate AGF347 Inhibitor
![]() Mono view ![]() Stereo pair view
Reference:
J.M.Katinas,
M.J.Nayeen,
M.Schneider,
K.Shah,
A.N.Fifer,
L.M.Klapper,
A.Sharma,
K.Thalluri,
M.S.Van Nieuwenhze,
Z.Hou,
A.Gangjee,
L.H.Matherly,
C.E.Dann 3Rd.
Structural Characterization of 5-Substituted Pyrrolo[3,2- D ]Pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2. Biochemistry 2024.
Page generated: Wed Jul 16 08:30:00 2025
ISSN: ISSN 0006-2960 PubMed: 38324671 DOI: 10.1021/ACS.BIOCHEM.3C00613 |
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