Fluorine in PDB 8thg: Cryo-Em Structure of NAV1.7 with Rlz

The binding sites of Fluorine atom in the Cryo-Em Structure of NAV1.7 with Rlz (pdb code 8thg). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Cryo-Em Structure of NAV1.7 with Rlz, PDB code: 8thg:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in the Cryo-Em Structure of NAV1.7 with Rlz


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of NAV1.7 with Rlz within 5.0Å range: probe atom residue distance (Å) B Occ A:F2003 b:20.0 occ:1.00 F1 A:6572003 0.0 20.0 1.0 C7 A:6572003 1.4 20.0 1.0 F3 A:6572003 2.2 20.0 1.0 F2 A:6572003 2.2 20.0 1.0 O1 A:6572003 2.2 20.0 1.0 C6 A:6572003 3.5 20.0 1.0 OE1 A:GLN360 3.6 107.8 1.0 CE1 A:PHE391 3.7 115.7 1.0 C5 A:6572003 4.0 20.0 1.0 CZ A:PHE391 4.2 109.0 1.0 OH A:TYR1755 4.6 134.3 1.0 CD A:GLN360 4.6 106.9 1.0 C1 A:6572003 4.8 20.0 1.0 CD1 A:PHE391 4.8 128.9 1.0 O A:THR1696 4.9 93.8 1.0 NE2 A:GLN360 4.9 114.5 1.0

Fluorine binding site 2 out of 3 in the Cryo-Em Structure of NAV1.7 with Rlz


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of NAV1.7 with Rlz within 5.0Å range: probe atom residue distance (Å) B Occ A:F2003 b:20.0 occ:1.00 F2 A:6572003 0.0 20.0 1.0 C7 A:6572003 1.4 20.0 1.0 F3 A:6572003 2.2 20.0 1.0 F1 A:6572003 2.2 20.0 1.0 O1 A:6572003 2.3 20.0 1.0 C5 A:6572003 2.7 20.0 1.0 C6 A:6572003 2.8 20.0 1.0 C4 A:6572003 4.1 20.0 1.0 C1 A:6572003 4.1 20.0 1.0 CG1 A:VAL1751 4.6 122.9 1.0 CE1 A:PHE391 5.0 115.7 1.0

Fluorine binding site 3 out of 3 in the Cryo-Em Structure of NAV1.7 with Rlz


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of NAV1.7 with Rlz within 5.0Å range: probe atom residue distance (Å) B Occ A:F2003 b:20.0 occ:1.00 F3 A:6572003 0.0 20.0 1.0 C7 A:6572003 1.4 20.0 1.0 F1 A:6572003 2.2 20.0 1.0 F2 A:6572003 2.2 20.0 1.0 O1 A:6572003 2.3 20.0 1.0 C5 A:6572003 2.5 20.0 1.0 C6 A:6572003 2.7 20.0 1.0 C4 A:6572003 3.9 20.0 1.0 O A:THR1696 4.1 93.8 1.0 C1 A:6572003 4.1 20.0 1.0 OE1 A:GLN360 4.8 107.8 1.0 S1 A:6572003 4.9 20.0 1.0 CB A:SER1697 4.9 97.2 1.0 C3 A:6572003 5.0 20.0 1.0

J.Huang, X.Fan, X.Jin, L.Teng, N.Yan. Dual-Pocket Inhibition of Na V Channels By the Antiepileptic Drug Lamotrigine. Proc.Natl.Acad.Sci.Usa V. 120 73120 2023.
ISSN: ESSN 1091-6490
PubMed: 37782796
DOI: 10.1073/PNAS.2309773120