Fluorine in PDB 8uaa: CDC48-SHP1 Unfolding Native Substrate, Class 3

All present enzymatic activity of CDC48-SHP1 Unfolding Native Substrate, Class 3:
3.6.4.6;

The structure of CDC48-SHP1 Unfolding Native Substrate, Class 3 also contains other interesting chemical elements:

Magnesium

(Mg)

8 atoms

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 24;

Binding sites:

The binding sites of Fluorine atom in the CDC48-SHP1 Unfolding Native Substrate, Class 3 (pdb code 8uaa). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 24 binding sites of Fluorine where determined in the CDC48-SHP1 Unfolding Native Substrate, Class 3, PDB code: 8uaa:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 24 in the CDC48-SHP1 Unfolding Native Substrate, Class 3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of CDC48-SHP1 Unfolding Native Substrate, Class 3 within 5.0Å range: probe atom residue distance (Å) B Occ A:F901 b:92.4 occ:1.00 F1 A:08T901 0.0 92.4 1.0 BE A:08T901 1.5 91.0 1.0 MG A:MG902 2.0 98.4 1.0 F3 A:08T901 2.5 95.8 1.0 F2 A:08T901 2.6 95.3 1.0 O3B A:08T901 2.6 83.8 1.0 O2B A:08T901 2.7 98.6 1.0 PB A:08T901 3.1 83.3 1.0 OD1 A:ASN358 3.7 119.8 1.0 OG1 A:THR262 4.1 96.7 1.0 O3A A:08T901 4.3 95.4 1.0 CB A:LYS261 4.3 90.1 1.0 O1B A:08T901 4.3 85.0 1.0 CE A:LYS261 4.3 96.1 1.0 CD A:LYS261 4.4 98.3 1.0 CG A:ASN358 4.5 117.7 1.0 ND2 A:ASN358 4.6 122.5 1.0 NH2 B:ARG372 4.6 91.5 1.0 CG A:LYS261 4.6 94.2 1.0 N A:GLY258 4.8 88.6 1.0 N A:THR262 4.8 94.7 1.0 OE2 A:GLU315 4.9 132.3 1.0

Fluorine binding site 2 out of 24 in the CDC48-SHP1 Unfolding Native Substrate, Class 3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of CDC48-SHP1 Unfolding Native Substrate, Class 3 within 5.0Å range: probe atom residue distance (Å) B Occ A:F901 b:95.3 occ:1.00 F2 A:08T901 0.0 95.3 1.0 BE A:08T901 1.6 91.0 1.0 F3 A:08T901 2.5 95.8 1.0 F1 A:08T901 2.6 92.4 1.0 O3B A:08T901 2.6 83.8 1.0 N A:GLY258 2.7 88.6 1.0 CA A:PRO257 3.2 84.9 1.0 CE A:LYS261 3.2 96.1 1.0 OD1 A:ASN358 3.2 119.8 1.0 C A:PRO257 3.4 85.0 1.0 PB A:08T901 3.4 83.3 1.0 O1B A:08T901 3.7 85.0 1.0 O2B A:08T901 3.7 98.6 1.0 CA A:GLY258 3.7 88.7 1.0 O A:PRO256 3.8 88.8 1.0 N A:THR259 3.9 82.5 1.0 NZ A:LYS261 4.0 93.4 1.0 CD A:LYS261 4.1 98.3 1.0 CB A:PRO257 4.1 87.4 1.0 MG A:MG902 4.2 98.4 1.0 OG1 A:THR259 4.2 92.2 1.0 N A:PRO257 4.2 87.2 1.0 C A:GLY258 4.3 85.5 1.0 CG A:LYS261 4.4 94.2 1.0 C A:PRO256 4.4 89.3 1.0 CG A:ASN358 4.4 117.7 1.0 O A:PRO257 4.6 83.6 1.0 CB A:LYS261 4.8 90.1 1.0 O3A A:08T901 4.9 95.4 1.0

Fluorine binding site 3 out of 24 in the CDC48-SHP1 Unfolding Native Substrate, Class 3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of CDC48-SHP1 Unfolding Native Substrate, Class 3 within 5.0Å range: probe atom residue distance (Å) B Occ A:F901 b:95.8 occ:1.00 F3 A:08T901 0.0 95.8 1.0 BE A:08T901 1.5 91.0 1.0 F2 A:08T901 2.5 95.3 1.0 F1 A:08T901 2.5 92.4 1.0 O3B A:08T901 2.6 83.8 1.0 OD1 A:ASN358 2.9 119.8 1.0 NH2 B:ARG372 3.4 91.5 1.0 N A:GLY258 3.6 88.6 1.0 CB A:PRO257 3.8 87.4 1.0 CA A:PRO257 3.9 84.9 1.0 CG A:ASN358 3.9 117.7 1.0 MG A:MG902 3.9 98.4 1.0 PB A:08T901 4.0 83.3 1.0 NH1 B:ARG372 4.0 93.2 1.0 NE B:ARG369 4.1 92.2 1.0 ND2 A:ASN358 4.2 122.5 1.0 CZ B:ARG372 4.2 89.5 1.0 C A:PRO257 4.2 85.0 1.0 O2B A:08T901 4.4 98.6 1.0 CA A:GLY258 4.6 88.7 1.0 NH2 B:ARG369 4.6 98.9 1.0 CZ B:ARG369 4.7 97.6 1.0 O3A A:08T901 4.9 95.4 1.0 CD B:ARG369 4.9 92.7 1.0 O1B A:08T901 4.9 85.0 1.0

Fluorine binding site 4 out of 24 in the CDC48-SHP1 Unfolding Native Substrate, Class 3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of CDC48-SHP1 Unfolding Native Substrate, Class 3 within 5.0Å range: probe atom residue distance (Å) B Occ A:F903 b:71.5 occ:1.00 F1 A:08T903 0.0 71.5 1.0 BE A:08T903 1.5 77.5 1.0 MG A:MG904 1.8 69.6 1.0 F3 A:08T903 2.5 84.0 1.0 F2 A:08T903 2.6 76.8 1.0 O3B A:08T903 2.6 73.8 1.0 O2B A:08T903 2.6 72.4 1.0 PB A:08T903 3.0 67.9 1.0 OG1 A:THR535 3.5 68.8 1.0 O1A A:08T903 3.5 74.1 1.0 NH2 B:ARG648 3.8 80.1 1.0 O3A A:08T903 3.8 62.4 1.0 OD2 B:ASP619 3.9 85.2 1.0 PA A:08T903 4.3 72.1 1.0 OE2 A:GLU588 4.3 95.3 1.0 O1B A:08T903 4.4 75.3 1.0 CB A:THR535 4.5 61.0 1.0 CZ B:ARG648 4.7 74.8 1.0 NH1 B:ARG648 4.7 70.7 1.0 O2A A:08T903 4.9 68.8 1.0 N A:THR535 5.0 60.9 1.0

Fluorine binding site 5 out of 24 in the CDC48-SHP1 Unfolding Native Substrate, Class 3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of CDC48-SHP1 Unfolding Native Substrate, Class 3 within 5.0Å range: probe atom residue distance (Å) B Occ A:F903 b:76.8 occ:1.00 F2 A:08T903 0.0 76.8 1.0 BE A:08T903 1.6 77.5 1.0 F3 A:08T903 2.5 84.0 1.0 F1 A:08T903 2.6 71.5 1.0 O3B A:08T903 2.6 73.8 1.0 PB A:08T903 3.6 67.9 1.0 O2B A:08T903 3.7 72.4 1.0 CA A:PRO530 3.9 66.9 1.0 CB A:PRO530 3.9 67.6 1.0 OE2 A:GLU588 4.1 95.3 1.0 MG A:MG904 4.1 69.6 1.0 CB A:ASN634 4.2 75.0 1.0 O1B A:08T903 4.3 75.3 1.0 NH2 B:ARG648 4.3 80.1 1.0 NH1 B:ARG648 4.4 70.7 1.0 N A:GLY531 4.5 67.3 1.0 C A:PRO530 4.8 70.0 1.0 O3A A:08T903 4.9 62.4 1.0 CZ B:ARG648 4.9 74.8 1.0 N A:PRO530 4.9 63.1 1.0 NE B:ARG645 5.0 64.1 1.0

Fluorine binding site 6 out of 24 in the CDC48-SHP1 Unfolding Native Substrate, Class 3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of CDC48-SHP1 Unfolding Native Substrate, Class 3 within 5.0Å range: probe atom residue distance (Å) B Occ A:F903 b:84.0 occ:1.00 F3 A:08T903 0.0 84.0 1.0 BE A:08T903 1.5 77.5 1.0 NH1 B:ARG648 2.4 70.7 1.0 F2 A:08T903 2.5 76.8 1.0 F1 A:08T903 2.5 71.5 1.0 O3B A:08T903 2.6 73.8 1.0 NH2 B:ARG648 2.7 80.1 1.0 CZ B:ARG648 2.9 74.8 1.0 NE B:ARG645 3.1 64.1 1.0 NH2 B:ARG645 3.2 68.8 1.0 CZ B:ARG645 3.5 66.9 1.0 PB A:08T903 4.0 67.9 1.0 OD2 B:ASP619 4.0 85.2 1.0 CD B:ARG645 4.1 68.6 1.0 NE B:ARG648 4.2 73.9 1.0 MG A:MG904 4.3 69.6 1.0 O2B A:08T903 4.4 72.4 1.0 O1A A:08T903 4.5 74.1 1.0 CB A:PRO530 4.5 67.6 1.0 O3A A:08T903 4.5 62.4 1.0 N A:GLY531 4.6 67.3 1.0 NH1 B:ARG645 4.7 68.6 1.0 CG B:ASP619 4.8 87.9 1.0 CA A:PRO530 4.9 66.9 1.0

Fluorine binding site 7 out of 24 in the CDC48-SHP1 Unfolding Native Substrate, Class 3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of CDC48-SHP1 Unfolding Native Substrate, Class 3 within 5.0Å range: probe atom residue distance (Å) B Occ B:F901 b:56.4 occ:1.00 F1 B:08T901 0.0 56.4 1.0 BE B:08T901 1.5 60.7 1.0 MG B:MG902 1.9 68.9 1.0 F3 B:08T901 2.5 71.2 1.0 F2 B:08T901 2.6 70.7 1.0 O3B B:08T901 2.6 52.0 1.0 O2B B:08T901 2.7 65.2 1.0 PB B:08T901 3.1 59.0 1.0 OG1 B:THR262 3.1 62.8 1.0 NH2 C:ARG372 3.7 59.3 1.0 O3A B:08T901 4.0 63.9 1.0 CG B:LYS261 4.1 51.2 1.0 CB B:THR262 4.2 61.0 1.0 CD B:LYS261 4.4 55.3 1.0 O1B B:08T901 4.4 60.7 1.0 N B:THR262 4.8 60.0 1.0 CZ C:ARG372 5.0 56.3 1.0 O1A B:08T901 5.0 73.2 1.0 OD1 B:ASN358 5.0 74.7 1.0 O C:ASP343 5.0 69.4 1.0

Fluorine binding site 8 out of 24 in the CDC48-SHP1 Unfolding Native Substrate, Class 3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of CDC48-SHP1 Unfolding Native Substrate, Class 3 within 5.0Å range: probe atom residue distance (Å) B Occ B:F901 b:70.7 occ:1.00 F2 B:08T901 0.0 70.7 1.0 BE B:08T901 1.6 60.7 1.0 F3 B:08T901 2.5 71.2 1.0 F1 B:08T901 2.6 56.4 1.0 O3B B:08T901 2.6 52.0 1.0 OD1 B:ASN358 2.9 74.7 1.0 CE B:LYS261 3.3 50.8 1.0 CD B:LYS261 3.3 55.3 1.0 PB B:08T901 3.4 59.0 1.0 NZ B:LYS261 3.4 66.0 1.0 O2B B:08T901 3.5 65.2 1.0 CA B:PRO257 3.5 55.4 1.0 CG B:LYS261 3.6 51.2 1.0 CG B:ASN358 3.8 69.4 1.0 N B:GLY258 3.9 58.5 1.0 O1B B:08T901 3.9 60.7 1.0 MG B:MG902 4.0 68.9 1.0 ND2 B:ASN358 4.1 69.9 1.0 O B:PRO256 4.1 58.1 1.0 CB B:PRO257 4.2 56.5 1.0 C B:PRO257 4.2 56.7 1.0 N B:PRO257 4.4 56.3 1.0 C B:PRO256 4.6 57.0 1.0 O B:GLY255 4.7 65.3 1.0 O3A B:08T901 4.8 63.9 1.0 NH2 C:ARG372 4.9 59.3 1.0

Fluorine binding site 9 out of 24 in the CDC48-SHP1 Unfolding Native Substrate, Class 3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of CDC48-SHP1 Unfolding Native Substrate, Class 3 within 5.0Å range: probe atom residue distance (Å) B Occ B:F901 b:71.2 occ:1.00 F3 B:08T901 0.0 71.2 1.0 BE B:08T901 1.5 60.7 1.0 F2 B:08T901 2.5 70.7 1.0 F1 B:08T901 2.5 56.4 1.0 NH2 C:ARG372 2.6 59.3 1.0 O3B B:08T901 2.6 52.0 1.0 CB B:PRO257 3.5 56.5 1.0 CA B:PRO257 3.7 55.4 1.0 CZ C:ARG372 3.9 56.3 1.0 N B:GLY258 3.9 58.5 1.0 OD1 B:ASN358 3.9 74.7 1.0 MG B:MG902 3.9 68.9 1.0 PB B:08T901 4.0 59.0 1.0 ND2 B:ASN358 4.1 69.9 1.0 NE C:ARG369 4.2 54.1 1.0 NH2 C:ARG369 4.3 66.6 1.0 C B:PRO257 4.3 56.7 1.0 CG B:ASN358 4.4 69.4 1.0 O2B B:08T901 4.4 65.2 1.0 NE C:ARG372 4.5 57.1 1.0 CZ C:ARG369 4.5 58.8 1.0 NH1 C:ARG372 4.8 61.0 1.0 O3A B:08T901 4.8 63.9 1.0 O1B B:08T901 4.9 60.7 1.0 N B:PRO257 5.0 56.3 1.0 CG B:PRO257 5.0 61.3 1.0 CA B:GLY258 5.0 61.0 1.0

Fluorine binding site 10 out of 24 in the CDC48-SHP1 Unfolding Native Substrate, Class 3


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of CDC48-SHP1 Unfolding Native Substrate, Class 3 within 5.0Å range: probe atom residue distance (Å) B Occ B:F903 b:72.9 occ:1.00 F1 B:08T903 0.0 72.9 1.0 BE B:08T903 1.5 65.6 1.0 MG B:MG904 1.9 62.9 1.0 O2B B:08T903 2.5 66.7 1.0 F3 B:08T903 2.5 66.1 1.0 F2 B:08T903 2.6 71.9 1.0 O3B B:08T903 2.6 57.4 1.0 PB B:08T903 3.0 58.9 1.0 NH2 C:ARG648 3.2 67.5 1.0 OG1 B:THR535 3.7 65.2 1.0 OE2 B:GLU588 3.8 73.6 1.0 O3A B:08T903 4.0 56.1 1.0 CZ C:ARG648 4.2 61.4 1.0 O1B B:08T903 4.3 62.5 1.0 NH1 C:ARG648 4.4 58.0 1.0 OD2 C:ASP619 4.5 68.3 1.0 NH2 C:ARG645 4.7 58.8 1.0 O C:ASP619 4.9 82.3 1.0 CD B:GLU588 4.9 76.1 1.0 CB B:THR535 5.0 59.7 1.0

I.Cooney, H.L.Schubert, K.Cedeno, O.N.Fisher, R.Carson, J.C.Price, C.P.Hill, P.S.Shen. Visualization of the CDC48 Aaa+ Atpase Protein Unfolding Pathway. Nat Commun V. 15 7505 2024.
ISSN: ESSN 2041-1723
PubMed: 39209885
DOI: 10.1038/S41467-024-51835-3