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Atomistry » Fluorine » PDB 8uq7-8v81 » 8v42 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 8uq7-8v81 » 8v42 » |
Fluorine in PDB 8v42: Structure of Human Vaccinia-Related Kinase 1 (VRK1) Bound to ACH000400Enzymatic activity of Structure of Human Vaccinia-Related Kinase 1 (VRK1) Bound to ACH000400
All present enzymatic activity of Structure of Human Vaccinia-Related Kinase 1 (VRK1) Bound to ACH000400:
2.7.11.1; Protein crystallography data
The structure of Structure of Human Vaccinia-Related Kinase 1 (VRK1) Bound to ACH000400, PDB code: 8v42
was solved by
R.M.Counago,
G.P.De Souza,
A.Azevedo,
C.Guimaraes,
A.Mascarello,
F.Gama,
M.Ferreira,
P.Arruda,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Human Vaccinia-Related Kinase 1 (VRK1) Bound to ACH000400
(pdb code 8v42). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Structure of Human Vaccinia-Related Kinase 1 (VRK1) Bound to ACH000400, PDB code: 8v42: Jump to Fluorine binding site number: 1; 2; 3; 4; Fluorine binding site 1 out of 4 in 8v42Go back to![]() ![]()
Fluorine binding site 1 out
of 4 in the Structure of Human Vaccinia-Related Kinase 1 (VRK1) Bound to ACH000400
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 4 in 8v42Go back to![]() ![]()
Fluorine binding site 2 out
of 4 in the Structure of Human Vaccinia-Related Kinase 1 (VRK1) Bound to ACH000400
![]() Mono view ![]() Stereo pair view
Fluorine binding site 3 out of 4 in 8v42Go back to![]() ![]()
Fluorine binding site 3 out
of 4 in the Structure of Human Vaccinia-Related Kinase 1 (VRK1) Bound to ACH000400
![]() Mono view ![]() Stereo pair view
Fluorine binding site 4 out of 4 in 8v42Go back to![]() ![]()
Fluorine binding site 4 out
of 4 in the Structure of Human Vaccinia-Related Kinase 1 (VRK1) Bound to ACH000400
![]() Mono view ![]() Stereo pair view
Reference:
F.H.De Souza Gama,
L.A.Dutra,
M.Hawgood,
C.V.Dos Reis,
R.A.M.Serafim,
M.A.Ferreira Jr.,
B.V.M.Teodoro,
J.E.Takarada,
A.S.Santiago,
D.I.Balourdas,
A.S.Nilsson,
B.Urien,
V.M.Almeida,
C.Gileadi,
P.Z.Ramos,
A.Salmazo,
S.N.S.Vasconcelos,
M.R.Cunha,
S.Mueller,
S.Knapp,
K.B.Massirer,
J.M.Elkins,
O.Gileadi,
A.Mascarello,
B.B.L.G.Lemmens,
C.R.W.Guimaraes,
H.Azevedo,
R.M.Counago.
Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1 Delta / Epsilon. J.Med.Chem. V. 67 8609 2024.
Page generated: Wed Jul 16 09:37:47 2025
ISSN: ISSN 0022-2623 PubMed: 38780468 DOI: 10.1021/ACS.JMEDCHEM.3C02250 |
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