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Fluorine in PDB 8w8r: Cryo-Em Structure of the Aa-14-Bound GPR101-Gs Complex

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Cryo-Em Structure of the Aa-14-Bound GPR101-Gs Complex (pdb code 8w8r). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Cryo-Em Structure of the Aa-14-Bound GPR101-Gs Complex, PDB code: 8w8r:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in 8w8r

Go back to Fluorine Binding Sites List in 8w8r
Fluorine binding site 1 out of 6 in the Cryo-Em Structure of the Aa-14-Bound GPR101-Gs Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of the Aa-14-Bound GPR101-Gs Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
R:F601

b:154.2
occ:1.00
F01 R:U7D601 0.0 154.2 1.0
C14 R:U7D601 1.4 154.0 1.0
F03 R:U7D601 2.2 153.6 1.0
F02 R:U7D601 2.2 153.8 1.0
C12 R:U7D601 2.4 153.5 1.0
C13 R:U7D601 2.7 154.0 1.0
C11 R:U7D601 3.6 152.0 1.0
C08 R:U7D601 4.1 154.0 1.0
C10 R:U7D601 4.7 153.3 1.0
C09 R:U7D601 4.9 153.9 1.0
N03 R:U7D601 4.9 154.3 1.0

Fluorine binding site 2 out of 6 in 8w8r

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Fluorine binding site 2 out of 6 in the Cryo-Em Structure of the Aa-14-Bound GPR101-Gs Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of the Aa-14-Bound GPR101-Gs Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
R:F601

b:153.8
occ:1.00
F02 R:U7D601 0.0 153.8 1.0
C14 R:U7D601 1.4 154.0 1.0
F01 R:U7D601 2.2 154.2 1.0
F03 R:U7D601 2.2 153.6 1.0
C12 R:U7D601 2.4 153.5 1.0
C11 R:U7D601 2.8 152.0 1.0
C13 R:U7D601 3.5 154.0 1.0
CZ3 R:TRP441 4.0 46.2 1.0
C10 R:U7D601 4.2 153.3 1.0
CH2 R:TRP441 4.4 45.3 1.0
C08 R:U7D601 4.7 154.0 1.0
CE3 R:TRP441 4.8 46.4 1.0
C09 R:U7D601 4.9 153.9 1.0

Fluorine binding site 3 out of 6 in 8w8r

Go back to Fluorine Binding Sites List in 8w8r
Fluorine binding site 3 out of 6 in the Cryo-Em Structure of the Aa-14-Bound GPR101-Gs Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of the Aa-14-Bound GPR101-Gs Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
R:F601

b:153.6
occ:1.00
F03 R:U7D601 0.0 153.6 1.0
C14 R:U7D601 1.4 154.0 1.0
F01 R:U7D601 2.2 154.2 1.0
F02 R:U7D601 2.2 153.8 1.0
C12 R:U7D601 2.4 153.5 1.0
CZ3 R:TRP441 3.0 46.2 1.0
C11 R:U7D601 3.1 152.0 1.0
C13 R:U7D601 3.3 154.0 1.0
CH2 R:TRP441 3.5 45.3 1.0
CE3 R:TRP441 4.2 46.4 1.0
C10 R:U7D601 4.3 153.3 1.0
C08 R:U7D601 4.5 154.0 1.0
CZ2 R:TRP441 4.8 43.9 1.0
C09 R:U7D601 4.9 153.9 1.0

Fluorine binding site 4 out of 6 in 8w8r

Go back to Fluorine Binding Sites List in 8w8r
Fluorine binding site 4 out of 6 in the Cryo-Em Structure of the Aa-14-Bound GPR101-Gs Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Structure of the Aa-14-Bound GPR101-Gs Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
R:F602

b:155.4
occ:1.00
F01 R:U7D602 0.0 155.4 1.0
C14 R:U7D602 1.4 156.2 1.0
F02 R:U7D602 2.2 155.7 1.0
F03 R:U7D602 2.2 155.5 1.0
C12 R:U7D602 2.4 156.3 1.0
C13 R:U7D602 2.7 155.4 1.0
OD1 R:ASN100 3.0 87.2 1.0
CB R:ASN100 3.2 81.9 1.0
CG R:ASN100 3.5 85.2 1.0
C11 R:U7D602 3.6 155.7 1.0
C08 R:U7D602 4.1 155.3 1.0
CA R:ASN100 4.6 83.1 1.0
C10 R:U7D602 4.7 155.3 1.0
ND2 R:ASN100 4.8 84.4 1.0
CB R:PHE103 4.8 68.8 1.0
C09 R:U7D602 4.9 155.6 1.0
N03 R:U7D602 5.0 154.9 1.0

Fluorine binding site 5 out of 6 in 8w8r

Go back to Fluorine Binding Sites List in 8w8r
Fluorine binding site 5 out of 6 in the Cryo-Em Structure of the Aa-14-Bound GPR101-Gs Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cryo-Em Structure of the Aa-14-Bound GPR101-Gs Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
R:F602

b:155.7
occ:1.00
F02 R:U7D602 0.0 155.7 1.0
C14 R:U7D602 1.4 156.2 1.0
F01 R:U7D602 2.2 155.4 1.0
F03 R:U7D602 2.2 155.5 1.0
C12 R:U7D602 2.4 156.3 1.0
C11 R:U7D602 3.2 155.7 1.0
C13 R:U7D602 3.2 155.4 1.0
C10 R:U7D602 4.4 155.3 1.0
C08 R:U7D602 4.4 155.3 1.0
OD1 R:ASN100 4.5 87.2 1.0
C09 R:U7D602 4.9 155.6 1.0

Fluorine binding site 6 out of 6 in 8w8r

Go back to Fluorine Binding Sites List in 8w8r
Fluorine binding site 6 out of 6 in the Cryo-Em Structure of the Aa-14-Bound GPR101-Gs Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Cryo-Em Structure of the Aa-14-Bound GPR101-Gs Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
R:F602

b:155.5
occ:1.00
F03 R:U7D602 0.0 155.5 1.0
C14 R:U7D602 1.4 156.2 1.0
F01 R:U7D602 2.2 155.4 1.0
F02 R:U7D602 2.2 155.7 1.0
C12 R:U7D602 2.4 156.3 1.0
C11 R:U7D602 2.8 155.7 1.0
C13 R:U7D602 3.6 155.4 1.0
C10 R:U7D602 4.1 155.3 1.0
CD1 R:PHE103 4.5 72.0 1.0
C08 R:U7D602 4.7 155.3 1.0
C09 R:U7D602 4.9 155.6 1.0
OD1 R:ASN100 4.9 87.2 1.0

Reference:

Z.Yang, J.Y.Wang, F.Yang, K.K.Zhu, G.P.Wang, Y.Guan, S.L.Ning, Y.Lu, Y.Li, C.Zhang, Y.Zheng, S.H.Zhou, X.W.Wang, M.W.Wang, P.Xiao, F.Yi, C.Zhang, P.J.Zhang, F.Xu, B.H.Liu, H.Zhang, X.Yu, N.Gao, J.P.Sun. Structure of GPR101-Gs Enables Identification of Ligands with Rejuvenating Potential. Nat.Chem.Biol. 2023.
ISSN: ESSN 1552-4469
PubMed: 37945893
DOI: 10.1038/S41589-023-01456-6
Page generated: Wed Jul 16 09:54:48 2025

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