Fluorine in PDB 8w8s: Cryo-Em Structure of the AA14-Bound GPR101 Complex

The binding sites of Fluorine atom in the Cryo-Em Structure of the AA14-Bound GPR101 Complex (pdb code 8w8s). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Cryo-Em Structure of the AA14-Bound GPR101 Complex, PDB code: 8w8s:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in the Cryo-Em Structure of the AA14-Bound GPR101 Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of the AA14-Bound GPR101 Complex within 5.0Å range: probe atom residue distance (Å) B Occ R:F601 b:241.1 occ:1.00 F01 R:U7D601 0.0 241.1 1.0 C14 R:U7D601 1.4 240.5 1.0 F03 R:U7D601 2.2 241.2 1.0 F02 R:U7D601 2.2 239.3 1.0 C12 R:U7D601 2.4 240.6 1.0 C13 R:U7D601 2.8 240.8 1.0 C11 R:U7D601 3.6 239.1 1.0 C08 R:U7D601 4.1 239.9 1.0 CZ3 R:TRP441 4.7 155.7 1.0 C10 R:U7D601 4.7 238.1 1.0 C09 R:U7D601 4.9 238.8 1.0 CH2 R:TRP441 5.0 156.3 1.0 N03 R:U7D601 5.0 240.4 1.0

Fluorine binding site 2 out of 6 in the Cryo-Em Structure of the AA14-Bound GPR101 Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of the AA14-Bound GPR101 Complex within 5.0Å range: probe atom residue distance (Å) B Occ R:F601 b:239.3 occ:1.00 F02 R:U7D601 0.0 239.3 1.0 C14 R:U7D601 1.4 240.5 1.0 F03 R:U7D601 2.2 241.2 1.0 F01 R:U7D601 2.2 241.1 1.0 C12 R:U7D601 2.4 240.6 1.0 C11 R:U7D601 2.7 239.1 1.0 CZ3 R:TRP441 3.2 155.7 1.0 CH2 R:TRP441 3.5 156.3 1.0 C13 R:U7D601 3.6 240.8 1.0 C10 R:U7D601 4.1 238.1 1.0 CE3 R:TRP441 4.3 157.0 1.0 CZ2 R:TRP441 4.7 152.9 1.0 C08 R:U7D601 4.7 239.9 1.0 C09 R:U7D601 4.9 238.8 1.0

Fluorine binding site 3 out of 6 in the Cryo-Em Structure of the AA14-Bound GPR101 Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of the AA14-Bound GPR101 Complex within 5.0Å range: probe atom residue distance (Å) B Occ R:F601 b:241.2 occ:1.00 F03 R:U7D601 0.0 241.2 1.0 C14 R:U7D601 1.4 240.5 1.0 F01 R:U7D601 2.2 241.1 1.0 F02 R:U7D601 2.2 239.3 1.0 C12 R:U7D601 2.4 240.6 1.0 CH2 R:TRP441 3.1 156.3 1.0 CZ3 R:TRP441 3.2 155.7 1.0 C13 R:U7D601 3.2 240.8 1.0 C11 R:U7D601 3.2 239.1 1.0 CZ2 R:TRP441 4.4 152.9 1.0 C08 R:U7D601 4.4 239.9 1.0 C10 R:U7D601 4.4 238.1 1.0 CE3 R:TRP441 4.5 157.0 1.0 C09 R:U7D601 4.9 238.8 1.0

Fluorine binding site 4 out of 6 in the Cryo-Em Structure of the AA14-Bound GPR101 Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Structure of the AA14-Bound GPR101 Complex within 5.0Å range: probe atom residue distance (Å) B Occ R:F602 b:263.5 occ:1.00 F01 R:U7D602 0.0 263.5 1.0 C14 R:U7D602 1.4 263.9 1.0 F02 R:U7D602 2.2 262.9 1.0 F03 R:U7D602 2.2 264.2 1.0 C12 R:U7D602 2.4 263.8 1.0 C13 R:U7D602 2.8 262.6 1.0 ND2 R:ASN100 3.1 197.6 1.0 C11 R:U7D602 3.6 263.5 1.0 CB R:ASN100 3.9 196.5 1.0 CG R:ASN100 4.0 196.6 1.0 C08 R:U7D602 4.1 261.9 1.0 C10 R:U7D602 4.7 262.5 1.0 C09 R:U7D602 4.9 261.7 1.0

Fluorine binding site 5 out of 6 in the Cryo-Em Structure of the AA14-Bound GPR101 Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cryo-Em Structure of the AA14-Bound GPR101 Complex within 5.0Å range: probe atom residue distance (Å) B Occ R:F602 b:262.9 occ:1.00 F02 R:U7D602 0.0 262.9 1.0 C14 R:U7D602 1.4 263.9 1.0 F01 R:U7D602 2.2 263.5 1.0 F03 R:U7D602 2.2 264.2 1.0 C12 R:U7D602 2.4 263.8 1.0 C13 R:U7D602 3.2 262.6 1.0 C11 R:U7D602 3.2 263.5 1.0 C08 R:U7D602 4.4 261.9 1.0 C10 R:U7D602 4.4 262.5 1.0 C09 R:U7D602 4.9 261.7 1.0

Fluorine binding site 6 out of 6 in the Cryo-Em Structure of the AA14-Bound GPR101 Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Cryo-Em Structure of the AA14-Bound GPR101 Complex within 5.0Å range: probe atom residue distance (Å) B Occ R:F602 b:264.2 occ:1.00 F03 R:U7D602 0.0 264.2 1.0 C14 R:U7D602 1.4 263.9 1.0 F02 R:U7D602 2.2 262.9 1.0 F01 R:U7D602 2.2 263.5 1.0 C12 R:U7D602 2.4 263.8 1.0 C11 R:U7D602 2.7 263.5 1.0 C13 R:U7D602 3.6 262.6 1.0 C10 R:U7D602 4.1 262.5 1.0 C08 R:U7D602 4.7 261.9 1.0 C09 R:U7D602 4.9 261.7 1.0

Z.Yang, J.Y.Wang, F.Yang, K.K.Zhu, G.P.Wang, Y.Guan, S.L.Ning, Y.Lu, Y.Li, C.Zhang, Y.Zheng, S.H.Zhou, X.W.Wang, M.W.Wang, P.Xiao, F.Yi, C.Zhang, P.J.Zhang, F.Xu, B.H.Liu, H.Zhang, X.Yu, N.Gao, J.P.Sun. Structure of GPR101-Gs Enables Identification of Ligands with Rejuvenating Potential. Nat.Chem.Biol. 2023.
ISSN: ESSN 1552-4469
PubMed: 37945893
DOI: 10.1038/S41589-023-01456-6