Fluorine in PDB 8wc7: Cryo-Em Structure of the ZH8667-Bound MTAAR1-Gs Complex

The binding sites of Fluorine atom in the Cryo-Em Structure of the ZH8667-Bound MTAAR1-Gs Complex (pdb code 8wc7). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Cryo-Em Structure of the ZH8667-Bound MTAAR1-Gs Complex, PDB code: 8wc7:

Fluorine binding site 1 out of 1 in the Cryo-Em Structure of the ZH8667-Bound MTAAR1-Gs Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of the ZH8667-Bound MTAAR1-Gs Complex within 5.0Å range: probe atom residue distance (Å) B Occ R:F401 b:86.4 occ:1.00 F01 R:VMK401 0.0 86.4 1.0 C11 R:VMK401 1.4 86.4 1.0 C10 R:VMK401 2.4 86.4 1.0 C12 R:VMK401 2.4 86.4 1.0 OG R:SER107 2.7 62.6 1.0 OH R:TYR153 3.0 85.8 1.0 CG2 R:ILE103 3.2 74.4 1.0 OG R:SER197 3.4 73.5 1.0 CB R:SER197 3.5 73.5 1.0 C09 R:VMK401 3.6 86.4 1.0 C13 R:VMK401 3.6 86.4 1.0 CE1 R:TYR153 3.9 85.8 1.0 CZ R:TYR153 3.9 85.8 1.0 C14 R:VMK401 4.1 86.4 1.0 CB R:SER107 4.1 62.6 1.0 O R:ILE103 4.2 74.4 1.0 CB R:ILE103 4.5 74.4 1.0 C R:ILE103 4.8 74.4 1.0 CA R:ILE103 4.8 74.4 1.0 C05 R:VMK401 4.9 86.4 1.0 CA R:SER197 5.0 73.5 1.0

P.Shang, N.Rong, J.J.Jiang, J.Cheng, M.H.Zhang, D.Kang, L.Qi, L.Guo, G.M.Yang, Q.Liu, Z.Zhou, X.B.Li, K.K.Zhu, Q.B.Meng, X.Han, W.Yan, Y.Kong, L.Yang, X.Wang, D.Lei, X.Feng, X.Liu, X.Yu, Y.Wang, Q.Li, Z.H.Shao, F.Yang, J.P.Sun. Structural and Signaling Mechanisms of TAAR1 Enabled Preferential Agonist Design. Cell V. 186 5347 2023.
ISSN: ISSN 1097-4172
PubMed: 37963465
DOI: 10.1016/J.CELL.2023.10.014