Fluorine in PDB 8x5y: Cryoem Structure of the Histamine H1 Receptor-Bril/Anti Bril Fab Complex with Astemizole

The binding sites of Fluorine atom in the Cryoem Structure of the Histamine H1 Receptor-Bril/Anti Bril Fab Complex with Astemizole (pdb code 8x5y). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Cryoem Structure of the Histamine H1 Receptor-Bril/Anti Bril Fab Complex with Astemizole, PDB code: 8x5y:

Fluorine binding site 1 out of 1 in the Cryoem Structure of the Histamine H1 Receptor-Bril/Anti Bril Fab Complex with Astemizole


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryoem Structure of the Histamine H1 Receptor-Bril/Anti Bril Fab Complex with Astemizole within 5.0Å range: probe atom residue distance (Å) B Occ B:F601 b:101.8 occ:1.00 F1 B:XB7601 0.0 101.8 1.0 C24 B:XB7601 1.4 101.8 1.0 C23 B:XB7601 2.3 101.8 1.0 C25 B:XB7601 2.5 101.8 1.0 CD1 B:PHE199 3.5 99.6 1.0 CG1 B:ILE115 3.7 99.5 1.0 C26 B:XB7601 3.7 101.8 1.0 CE1 B:PHE199 3.7 99.6 1.0 C22 B:XB7601 3.8 101.8 1.0 CB B:ILE115 3.9 99.5 1.0 CD1 B:TRP428 4.1 103.1 1.0 CE2 B:PHE432 4.1 100.0 1.0 CG B:TRP428 4.1 103.1 1.0 CE2 B:PHE424 4.2 104.5 1.0 C21 B:XB7601 4.2 101.8 1.0 O B:SER111 4.3 97.9 1.0 CD2 B:PHE424 4.3 104.5 1.0 NE1 B:TRP428 4.4 103.1 1.0 CB B:TRP428 4.5 103.1 1.0 CD2 B:TRP428 4.5 103.1 1.0 CG2 B:ILE115 4.5 99.5 1.0 CD1 B:ILE115 4.7 99.5 1.0 CE2 B:TRP428 4.7 103.1 1.0 CZ B:PHE432 4.7 100.0 1.0 CG B:PHE199 4.8 99.6 1.0 CD2 B:PHE432 4.9 100.0 1.0

D.Wang, Q.Guo, Z.Wu, M.Li, B.He, Y.Du, K.Zhang, Y.Tao. Molecular Mechanism of Antihistamines Recognition and Regulation of the Histamine H 1 Receptor. Nat Commun V. 15 84 2024.
ISSN: ESSN 2041-1723
PubMed: 38167898
DOI: 10.1038/S41467-023-44477-4