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Fluorine in PDB 8zbt: Cryo-Em Structure of Nanodisc-Reconstituted Human MRP4 WITHE1202Q Mutation (in Complex with 5-Fluorouracil)

Enzymatic activity of Cryo-Em Structure of Nanodisc-Reconstituted Human MRP4 WITHE1202Q Mutation (in Complex with 5-Fluorouracil)

All present enzymatic activity of Cryo-Em Structure of Nanodisc-Reconstituted Human MRP4 WITHE1202Q Mutation (in Complex with 5-Fluorouracil):
7.6.2.2; 7.6.2.3;

Other elements in 8zbt:

The structure of Cryo-Em Structure of Nanodisc-Reconstituted Human MRP4 WITHE1202Q Mutation (in Complex with 5-Fluorouracil) also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Cryo-Em Structure of Nanodisc-Reconstituted Human MRP4 WITHE1202Q Mutation (in Complex with 5-Fluorouracil) (pdb code 8zbt). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Cryo-Em Structure of Nanodisc-Reconstituted Human MRP4 WITHE1202Q Mutation (in Complex with 5-Fluorouracil), PDB code: 8zbt:

Fluorine binding site 1 out of 1 in 8zbt

Go back to Fluorine Binding Sites List in 8zbt
Fluorine binding site 1 out of 1 in the Cryo-Em Structure of Nanodisc-Reconstituted Human MRP4 WITHE1202Q Mutation (in Complex with 5-Fluorouracil)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of Nanodisc-Reconstituted Human MRP4 WITHE1202Q Mutation (in Complex with 5-Fluorouracil) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1401

b:68.5
occ:1.00
F5 A:URF1401 0.0 68.5 1.0
C5 A:URF1401 1.3 68.5 1.0
C6 A:URF1401 2.3 68.5 1.0
C4 A:URF1401 2.4 68.5 1.0
O4 A:URF1401 2.8 68.5 1.0
CZ3 A:TRP995 3.4 63.5 1.0
CH2 A:TRP995 3.4 63.5 1.0
N3 A:URF1401 3.6 68.5 1.0
N1 A:URF1401 3.6 68.5 1.0
CE3 A:TRP995 3.7 63.5 1.0
CZ2 A:TRP995 3.8 63.5 1.0
CD1 A:LEU367 4.0 66.8 1.0
CD2 A:TRP995 4.1 63.5 1.0
CE2 A:TRP995 4.1 63.5 1.0
C2 A:URF1401 4.1 68.5 1.0
CG A:LEU367 4.7 66.8 1.0
NE1 A:TRP995 5.0 63.5 1.0

Reference:

Z.Xie, J.Lv, W.Huang, Z.Wu, R.Zhu, Z.Deng, F.Long. Structural Basis For the Reversal of Human MRP4-Mediated Multidrug Resistance By Lapatinib. Cell Rep V. 44 15466 2025.
ISSN: ESSN 2211-1247
PubMed: 40138312
DOI: 10.1016/J.CELREP.2025.115466
Page generated: Wed Jul 16 10:16:31 2025

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