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Fluorine in PDB 9jf9: Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation

Enzymatic activity of Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation

All present enzymatic activity of Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation:
2.7.10.1;

Fluorine Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Fluorine atom in the Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation (pdb code 9jf9). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 12 binding sites of Fluorine where determined in the Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation, PDB code: 9jf9:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 12 in 9jf9

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Fluorine binding site 1 out of 12 in the Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F2

b:404.7
occ:1.00
F C:AF22 0.0 404.7 1.0
C2' C:AF22 1.4 404.7 1.0
C3' C:AF22 2.2 404.7 1.0
O3' C:AF22 2.3 404.7 1.0
C1' C:AF22 2.5 404.7 1.0
C4' C:AF22 3.4 404.7 1.0
N9 C:AF22 3.4 404.7 1.0
P C:DUZ3 3.4 332.2 1.0
OP2 C:DUZ3 3.4 332.2 1.0
O4' C:DUZ3 3.4 332.2 1.0
O4' C:AF22 3.4 404.7 1.0
O22 C:DUZ3 3.5 332.2 1.0
C5' C:DUZ3 3.7 332.2 1.0
C6 C:DUZ3 3.7 332.2 1.0
C26 C:85Y20 3.8 270.0 1.0
C30 C:85Y20 3.9 270.0 1.0
C8 C:AF22 4.0 404.7 1.0
C4' C:DUZ3 4.1 332.2 1.0
O5' C:DUZ3 4.1 332.2 1.0
C27 C:85Y20 4.1 270.0 1.0
C25 C:85Y20 4.2 270.0 1.0
C31 C:85Y20 4.2 270.0 1.0
C21 C:DUZ3 4.3 332.2 1.0
C4 C:AF22 4.3 404.7 1.0
C5 C:DUZ3 4.4 332.2 1.0
C33 C:85Y20 4.5 270.0 1.0
C32 C:85Y20 4.5 270.0 1.0
C5' C:AF22 4.5 404.7 1.0
N1 C:DUZ3 4.6 332.2 1.0
OP1 C:DUZ3 4.6 332.2 1.0
C1' C:DUZ3 4.7 332.2 1.0
O5' C:AF22 4.7 404.7 1.0
C28 C:85Y20 4.7 270.0 1.0
C24 C:85Y20 4.8 270.0 1.0
N3 C:AF22 4.8 404.7 1.0

Fluorine binding site 2 out of 12 in 9jf9

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Fluorine binding site 2 out of 12 in the Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F6

b:270.0
occ:1.00
F2' C:CFZ6 0.0 270.0 1.0
C2' C:CFZ6 1.4 270.0 1.0
C3' C:CFZ6 2.2 270.0 1.0
OP2 C:DG7 2.5 222.2 1.0
O3' C:CFZ6 2.6 270.0 1.0
C1' C:CFZ6 2.6 270.0 1.0
C8 C:DG7 2.8 222.2 1.0
P C:DG7 3.1 222.2 1.0
N7 C:DG7 3.2 222.2 1.0
N1 C:CFZ6 3.3 270.0 1.0
C6 C:CFZ6 3.5 270.0 1.0
C4' C:CFZ6 3.5 270.0 1.0
O4' C:CFZ6 3.6 270.0 1.0
N9 C:DG7 4.0 222.2 1.0
OP1 C:DG7 4.0 222.2 1.0
C5' C:CFZ6 4.2 270.0 1.0
O5' C:CFZ6 4.3 270.0 1.0
O5' C:DG7 4.3 222.2 1.0
C5 C:DG7 4.4 222.2 1.0
C2 C:CFZ6 4.5 270.0 1.0
C2' C:DG7 4.6 222.2 1.0
C1' C:DG7 4.7 222.2 1.0
O4' C:DG7 4.7 222.2 1.0
C5' C:DG7 4.7 222.2 1.0
C5 C:CFZ6 4.8 270.0 1.0
O2P C:CFZ6 4.8 270.0 1.0
C4 C:DG7 4.8 222.2 1.0
O2 C:CFZ6 4.9 270.0 1.0

Fluorine binding site 3 out of 12 in 9jf9

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Fluorine binding site 3 out of 12 in the Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F8

b:270.0
occ:1.00
F2' C:CFZ8 0.0 270.0 1.0
C2' C:CFZ8 1.4 270.0 1.0
C3' C:CFZ8 2.2 270.0 1.0
O3' C:CFZ8 2.3 270.0 1.0
C1' C:CFZ8 2.5 270.0 1.0
O5' C:DA9 2.8 194.9 1.0
P C:DA9 3.1 194.9 1.0
CD2 A:PHE39 3.2 212.2 1.0
OH A:TYR67 3.4 223.2 1.0
N1 C:CFZ8 3.4 270.0 1.0
C6 C:CFZ8 3.4 270.0 1.0
C4' C:CFZ8 3.4 270.0 1.0
O4' C:CFZ8 3.5 270.0 1.0
CE2 A:PHE39 3.6 212.2 1.0
OP2 C:DA9 3.8 194.9 1.0
CZ A:TYR67 4.0 223.2 1.0
C5' C:DA9 4.0 194.9 1.0
CE2 A:TYR67 4.1 223.2 1.0
OP1 C:DA9 4.3 194.9 1.0
CG A:PHE39 4.4 212.2 1.0
C5' C:CFZ8 4.5 270.0 1.0
C32 C:85Y10 4.5 162.1 1.0
C31 C:85Y10 4.5 162.1 1.0
CB A:PHE39 4.8 212.2 1.0
C2 C:CFZ8 4.8 270.0 1.0
C5 C:CFZ8 4.8 270.0 1.0
CZ A:PHE39 4.9 212.2 1.0
CE1 A:TYR67 5.0 223.2 1.0
C2' C:DG7 5.0 222.2 1.0

Fluorine binding site 4 out of 12 in 9jf9

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Fluorine binding site 4 out of 12 in the Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F12

b:270.0
occ:1.00
F C:AF212 0.0 270.0 1.0
C2' C:AF212 1.4 270.0 1.0
C3' C:AF212 2.3 270.0 1.0
O3' C:AF212 2.4 270.0 1.0
C1' C:AF212 2.5 270.0 1.0
OP2 C:OMG13 2.8 190.6 1.0
P C:OMG13 3.1 190.6 1.0
N9 C:AF212 3.3 270.0 1.0
C4' C:AF212 3.4 270.0 1.0
O4' C:AF212 3.5 270.0 1.0
OP1 C:OMG13 3.8 190.6 1.0
C4 C:AF212 4.0 270.0 1.0
C8 C:AF212 4.0 270.0 1.0
N3 C:AF212 4.3 270.0 1.0
O5' C:OMG13 4.4 190.6 1.0
C5' C:AF212 4.6 270.0 1.0
C5 C:AF212 4.9 270.0 1.0
N7 C:AF212 5.0 270.0 1.0

Fluorine binding site 5 out of 12 in 9jf9

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Fluorine binding site 5 out of 12 in the Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F19

b:275.5
occ:1.00
F C:AF219 0.0 275.5 1.0
C2' C:AF219 1.4 275.5 1.0
C3' C:AF219 2.2 275.5 1.0
O3' C:AF219 2.4 275.5 1.0
C1' C:AF219 2.5 275.5 1.0
N9 C:AF219 3.2 275.5 1.0
C4' C:AF219 3.5 275.5 1.0
P C:85Y20 3.5 270.0 1.0
O4' C:AF219 3.5 275.5 1.0
OP2 C:85Y20 3.6 270.0 1.0
C4 C:AF219 3.7 275.5 1.0
CD2 B:LEU486 3.8 161.6 1.0
N3 C:AF219 3.9 275.5 1.0
OP1 C:85Y20 4.0 270.0 1.0
C8 C:AF219 4.0 275.5 1.0
CG B:LEU486 4.4 161.6 1.0
C5' C:AF219 4.5 275.5 1.0
C5 C:AF219 4.7 275.5 1.0
N4 C:OMC21 4.8 210.7 1.0
N7 C:AF219 4.9 275.5 1.0
O5' C:85Y20 4.9 270.0 1.0
CD2 B:LEU552 5.0 124.1 1.0
C2 C:AF219 5.0 275.5 1.0

Fluorine binding site 6 out of 12 in 9jf9

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Fluorine binding site 6 out of 12 in the Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F22

b:270.0
occ:1.00
F2' C:CFZ22 0.0 270.0 1.0
C2' C:CFZ22 1.4 270.0 1.0
C3' C:CFZ22 2.2 270.0 1.0
O3' C:CFZ22 2.3 270.0 1.0
O4' C:DG23 2.3 173.2 1.0
C1' C:CFZ22 2.5 270.0 1.0
O5' C:DG23 2.7 173.2 1.0
O2 C:CFZ22 2.9 270.0 1.0
C8 C:DG23 2.9 173.2 1.0
C5' C:DG23 3.0 173.2 1.0
P C:DG23 3.1 173.2 1.0
N1 C:CFZ22 3.2 270.0 1.0
C4' C:DG23 3.2 173.2 1.0
C2 C:CFZ22 3.3 270.0 1.0
N9 C:DG23 3.4 173.2 1.0
C1' C:DG23 3.4 173.2 1.0
C4' C:CFZ22 3.4 270.0 1.0
O4' C:CFZ22 3.5 270.0 1.0
OP2 C:DG23 3.5 173.2 1.0
N7 C:DG23 3.9 173.2 1.0
C3' C:DG23 4.1 173.2 1.0
OP1 C:DG23 4.3 173.2 1.0
C2' C:DG23 4.4 173.2 1.0
C6 C:CFZ22 4.4 270.0 1.0
C4 C:DG23 4.5 173.2 1.0
C5' C:CFZ22 4.6 270.0 1.0
N3 C:CFZ22 4.6 270.0 1.0
O5' C:CFZ22 4.6 270.0 1.0
C5 C:DG23 4.7 173.2 1.0

Fluorine binding site 7 out of 12 in 9jf9

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Fluorine binding site 7 out of 12 in the Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F2

b:317.4
occ:1.00
F D:AF22 0.0 317.4 1.0
C2' D:AF22 1.4 317.4 1.0
C3' D:AF22 2.2 317.4 1.0
O3' D:AF22 2.3 317.4 1.0
C1' D:AF22 2.5 317.4 1.0
C4' D:AF22 3.2 317.4 1.0
O4' D:DUZ3 3.4 301.7 1.0
C30 D:85Y20 3.4 188.0 1.0
O4' D:AF22 3.4 317.4 1.0
N9 D:AF22 3.5 317.4 1.0
C26 D:85Y20 3.5 188.0 1.0
O22 D:DUZ3 3.7 301.7 1.0
C31 D:85Y20 3.7 188.0 1.0
P D:DUZ3 3.7 301.7 1.0
C6 D:DUZ3 3.8 301.7 1.0
C5' D:DUZ3 4.0 301.7 1.0
C25 D:85Y20 4.0 188.0 1.0
C27 D:85Y20 4.0 188.0 1.0
OP2 D:DUZ3 4.0 301.7 1.0
C4' D:DUZ3 4.1 301.7 1.0
C32 D:85Y20 4.2 188.0 1.0
C8 D:AF22 4.2 317.4 1.0
C4 D:AF22 4.2 317.4 1.0
C33 D:85Y20 4.3 188.0 1.0
O5' D:DUZ3 4.4 301.7 1.0
C5' D:AF22 4.5 317.4 1.0
C21 D:DUZ3 4.5 301.7 1.0
N3 D:AF22 4.6 317.4 1.0
C5 D:DUZ3 4.7 301.7 1.0
C1' D:DUZ3 4.7 301.7 1.0
OP1 D:DUZ3 4.8 301.7 1.0
N1 D:DUZ3 4.8 301.7 1.0
C24 D:85Y20 4.8 188.0 1.0
C28 D:85Y20 4.8 188.0 1.0
O5' D:AF22 4.8 317.4 1.0

Fluorine binding site 8 out of 12 in 9jf9

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Fluorine binding site 8 out of 12 in the Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F6

b:270.0
occ:1.00
F2' D:CFZ6 0.0 270.0 1.0
C2' D:CFZ6 1.4 270.0 1.0
C3' D:CFZ6 2.2 270.0 1.0
O3' D:CFZ6 2.4 270.0 1.0
C1' D:CFZ6 2.6 270.0 1.0
C8 D:DG7 3.0 226.1 1.0
N1 D:CFZ6 3.1 270.0 1.0
C6 D:CFZ6 3.3 270.0 1.0
OP2 D:DG7 3.3 226.1 1.0
N7 D:DG7 3.4 226.1 1.0
P D:DG7 3.5 226.1 1.0
C4' D:CFZ6 3.5 270.0 1.0
O4' D:CFZ6 3.6 270.0 1.0
O2P D:CFZ6 3.9 270.0 1.0
N9 D:DG7 4.1 226.1 1.0
C5' D:CFZ6 4.3 270.0 1.0
O5' D:CFZ6 4.3 270.0 1.0
C2 D:CFZ6 4.4 270.0 1.0
O4' D:DG7 4.5 226.1 1.0
O5' D:DG7 4.5 226.1 1.0
OP1 D:DG7 4.5 226.1 1.0
C5 D:CFZ6 4.6 270.0 1.0
C5 D:DG7 4.6 226.1 1.0
C1' D:DG7 4.7 226.1 1.0
P D:CFZ6 4.8 270.0 1.0
C2' D:DG7 4.8 226.1 1.0
O2 D:CFZ6 4.8 270.0 1.0

Fluorine binding site 9 out of 12 in 9jf9

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Fluorine binding site 9 out of 12 in the Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F8

b:270.0
occ:1.00
F2' D:CFZ8 0.0 270.0 1.0
C2' D:CFZ8 1.4 270.0 1.0
C3' D:CFZ8 2.2 270.0 1.0
O3' D:CFZ8 2.3 270.0 1.0
C1' D:CFZ8 2.5 270.0 1.0
O5' D:DA9 2.9 270.0 1.0
P D:DA9 3.1 270.0 1.0
OH B:TYR67 3.2 267.9 1.0
C6 D:CFZ8 3.3 270.0 1.0
N1 D:CFZ8 3.4 270.0 1.0
C4' D:CFZ8 3.4 270.0 1.0
O4' D:CFZ8 3.5 270.0 1.0
OP2 D:DA9 3.7 270.0 1.0
CZ B:TYR67 3.7 267.9 1.0
CE2 B:TYR67 3.8 267.9 1.0
C5' D:DA9 3.9 270.0 1.0
C31 D:85Y10 4.1 270.0 1.0
C32 D:85Y10 4.1 270.0 1.0
OP1 D:DA9 4.4 270.0 1.0
C5' D:CFZ8 4.5 270.0 1.0
C2' D:DG7 4.5 226.1 1.0
C5 D:CFZ8 4.8 270.0 1.0
CE1 B:TYR67 4.8 267.9 1.0
C2 D:CFZ8 4.9 270.0 1.0
CD2 B:TYR67 4.9 267.9 1.0
O3' D:DG7 4.9 226.1 1.0
C30 D:85Y10 5.0 270.0 1.0

Fluorine binding site 10 out of 12 in 9jf9

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Fluorine binding site 10 out of 12 in the Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Human Insulin Receptor Bound with A62-Dimer, Pseudo-Arrowhead Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F12

b:270.0
occ:1.00
F D:AF212 0.0 270.0 1.0
C2' D:AF212 1.4 270.0 1.0
C3' D:AF212 2.2 270.0 1.0
O3' D:AF212 2.4 270.0 1.0
C1' D:AF212 2.5 270.0 1.0
OP2 D:OMG13 2.8 270.0 1.0
NE A:ARG554 3.0 192.4 1.0
P D:OMG13 3.1 270.0 1.0
NH2 A:ARG554 3.1 192.4 1.0
N9 D:AF212 3.3 270.0 1.0
CZ A:ARG554 3.4 192.4 1.0
C4' D:AF212 3.4 270.0 1.0
O4' D:AF212 3.5 270.0 1.0
C8 D:AF212 3.9 270.0 1.0
OP1 D:OMG13 3.9 270.0 1.0
CD A:ARG554 4.0 192.4 1.0
C4 D:AF212 4.1 270.0 1.0
O5' D:OMG13 4.4 270.0 1.0
C5' D:AF212 4.5 270.0 1.0
N3 D:AF212 4.6 270.0 1.0
NH1 A:ARG554 4.6 192.4 1.0
OP2 D:AF212 4.7 270.0 1.0
N7 D:AF212 4.9 270.0 1.0
O5' D:AF212 4.9 270.0 1.0
C5 D:AF212 5.0 270.0 1.0

Reference:

J.Kim, H.Na, S.Y.Choi, E.J.Oh, H.Lee, S.H.Ryu, N.O.Yunn, Y.Cho. Structural Mechanism of Insulin Receptor Activation By A Dimeric Aptamer Agonist. Exp.Mol.Med. 2025.
ISSN: ISSN 1226-3613
PubMed: 40603733
DOI: 10.1038/S12276-025-01494-1
Page generated: Mon Aug 4 22:23:31 2025

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