Fluorine in PDB 9vck: Cryo-Em Structure of Sars-Cov-2 NSP10/NSP14:Rna:Smp Complex

All present enzymatic activity of Cryo-Em Structure of Sars-Cov-2 NSP10/NSP14:Rna:Smp Complex:
2.1.1.56;

The structure of Cryo-Em Structure of Sars-Cov-2 NSP10/NSP14:Rna:Smp Complex also contains other interesting chemical elements:

Calcium	(Ca)	2 atoms
Zinc	(Zn)	5 atoms

The binding sites of Fluorine atom in the Cryo-Em Structure of Sars-Cov-2 NSP10/NSP14:Rna:Smp Complex (pdb code 9vck). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Cryo-Em Structure of Sars-Cov-2 NSP10/NSP14:Rna:Smp Complex, PDB code: 9vck:

Fluorine binding site 1 out of 1 in the Cryo-Em Structure of Sars-Cov-2 NSP10/NSP14:Rna:Smp Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of Sars-Cov-2 NSP10/NSP14:Rna:Smp Complex within 5.0Å range: probe atom residue distance (Å) B Occ P:F101 b:81.2 occ:1.00 F03 P:K5X101 0.0 81.2 1.0 C02 P:K5X101 1.4 81.2 1.0 C04 P:K5X101 2.2 81.2 1.0 O05 P:K5X101 2.4 81.2 1.0 C14 P:K5X101 2.4 81.2 1.0 C01 P:K5X101 2.5 81.2 1.0 C06 P:K5X101 2.8 81.2 1.0 O13 P:K5X101 3.2 81.2 1.0 N15 P:K5X101 3.5 81.2 1.0 O22 P:K5X101 3.5 81.2 1.0 O B:GLY93 3.5 80.1 1.0 N B:GLY93 3.7 80.1 1.0 C21 P:K5X101 3.9 81.2 1.0 C B:GLY93 4.0 80.1 1.0 ND2 B:ASN104 4.1 79.5 1.0 C07 P:K5X101 4.1 81.2 1.0 CA B:GLY93 4.2 80.1 1.0 C16 P:K5X101 4.5 81.2 1.0 CG B:ASN104 4.5 79.5 1.0 CE2 B:PHE190 4.6 74.5 1.0 C B:GLU92 4.7 80.5 1.0 CZ B:PHE190 4.8 74.5 1.0 CE1 B:HIS95 4.9 83.3 1.0 N B:CYS94 4.9 80.5 1.0 OD1 B:ASN104 4.9 79.5 1.0 CA B:GLU92 5.0 80.5 1.0

J.Wang, Y.Pan, Y.Liu, B.Huang, G.Jin, L.Zhang, F.Zhou, X.Chang, Y.Huang, L.Yan, Y.Dong, Z.Rao, D.Liu, Z.Lou. Structural Basis and Rational Design of Nucleotide Analogue Inhibitor Evading the Sars-Cov-2 Proofreading Enzyme. J.Am.Chem.Soc. V. 147 21896 2025.
ISSN: ESSN 1520-5126
PubMed: 40509573
DOI: 10.1021/JACS.5C05014