Fluorine in PDB 9vcl: Cryo-Em Structure of Sars-Cov-2 NSP10/NSP14:Rna:Atmp Complex

All present enzymatic activity of Cryo-Em Structure of Sars-Cov-2 NSP10/NSP14:Rna:Atmp Complex:
2.1.1.56;

The structure of Cryo-Em Structure of Sars-Cov-2 NSP10/NSP14:Rna:Atmp Complex also contains other interesting chemical elements:

Zinc	(Zn)	5 atoms
Calcium	(Ca)	2 atoms

The binding sites of Fluorine atom in the Cryo-Em Structure of Sars-Cov-2 NSP10/NSP14:Rna:Atmp Complex (pdb code 9vcl). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Cryo-Em Structure of Sars-Cov-2 NSP10/NSP14:Rna:Atmp Complex, PDB code: 9vcl:

Fluorine binding site 1 out of 1 in the Cryo-Em Structure of Sars-Cov-2 NSP10/NSP14:Rna:Atmp Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of Sars-Cov-2 NSP10/NSP14:Rna:Atmp Complex within 5.0Å range: probe atom residue distance (Å) B Occ P:F101 b:62.4 occ:0.97 F P:EIF101 0.0 62.4 1.0 C1 P:EIF101 1.4 62.4 1.0 C P:EIF101 2.3 62.4 1.0 C5 P:EIF101 2.3 62.4 1.0 C2 P:EIF101 2.4 62.4 1.0 O P:EIF101 2.7 62.4 1.0 O B:GLY93 2.8 36.9 1.0 C3 P:EIF101 2.8 62.4 1.0 O5 P:EIF101 3.0 62.4 1.0 N P:EIF101 3.5 62.4 1.0 CG B:PRO141 3.6 61.2 1.0 C B:GLY93 3.9 36.9 1.0 NE2 B:HIS95 3.9 53.0 1.0 N2 P:EIF101 4.0 62.4 1.0 CB B:PRO141 4.0 61.2 1.0 C8 P:EIF101 4.0 62.4 1.0 OD1 B:ASN104 4.1 36.8 1.0 C4 P:EIF101 4.2 62.4 1.0 N B:GLY93 4.4 36.9 1.0 CD2 B:HIS95 4.4 53.0 1.0 CA B:GLY93 4.5 36.9 1.0 C6 P:EIF101 4.6 62.4 1.0 O1 P:EIF101 4.9 62.4 1.0 N B:CYS94 4.9 41.9 1.0

J.Wang, Y.Pan, Y.Liu, B.Huang, G.Jin, L.Zhang, F.Zhou, X.Chang, Y.Huang, L.Yan, Y.Dong, Z.Rao, D.Liu, Z.Lou. Structural Basis and Rational Design of Nucleotide Analogue Inhibitor Evading the Sars-Cov-2 Proofreading Enzyme. J.Am.Chem.Soc. V. 147 21896 2025.
ISSN: ESSN 1520-5126
PubMed: 40509573
DOI: 10.1021/JACS.5C05014