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Atomistry » Fluorine » PDB 5ug9-5uv2 » 5usq | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5ug9-5uv2 » 5usq » |
Fluorine in PDB 5usq: Alk-5 Kinase Inhibitor ComplexEnzymatic activity of Alk-5 Kinase Inhibitor Complex
All present enzymatic activity of Alk-5 Kinase Inhibitor Complex:
2.7.11.30; Protein crystallography data
The structure of Alk-5 Kinase Inhibitor Complex, PDB code: 5usq
was solved by
D.R.Dougan,
J.D.Lawson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5usq:
The structure of Alk-5 Kinase Inhibitor Complex also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Alk-5 Kinase Inhibitor Complex
(pdb code 5usq). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Alk-5 Kinase Inhibitor Complex, PDB code: 5usq: Fluorine binding site 1 out of 1 in 5usqGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Alk-5 Kinase Inhibitor Complex
![]() Mono view ![]() Stereo pair view
Reference:
M.Sabat,
H.Wang,
N.Scorah,
J.D.Lawson,
J.Atienza,
R.Kamran,
M.S.Hixon,
D.R.Dougan.
Design, Synthesis and Optimization of 7-Substituted-Pyrazolo[4,3-B]Pyridine ALK5 (Activin Receptor-Like Kinase 5) Inhibitors. Bioorg. Med. Chem. Lett. V. 27 1955 2017.
Page generated: Tue Jul 15 08:18:09 2025
ISSN: ESSN 1464-3405 PubMed: 28359790 DOI: 10.1016/J.BMCL.2017.03.026 |
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