Fluorine in PDB 9jvw: Overall Structure of Human EAAT2 Bound with Inhibitor (Way-213613)
Other elements in 9jvw:
The structure of Overall Structure of Human EAAT2 Bound with Inhibitor (Way-213613) also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Overall Structure of Human EAAT2 Bound with Inhibitor (Way-213613)
(pdb code 9jvw). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the
Overall Structure of Human EAAT2 Bound with Inhibitor (Way-213613), PDB code: 9jvw:
Jump to Fluorine binding site number:
1;
2;
3;
4;
5;
6;
Fluorine binding site 1 out
of 6 in 9jvw
Go back to
Fluorine Binding Sites List in 9jvw
Fluorine binding site 1 out
of 6 in the Overall Structure of Human EAAT2 Bound with Inhibitor (Way-213613)
 Mono view
 Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Overall Structure of Human EAAT2 Bound with Inhibitor (Way-213613) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F1002
b:71.5
occ:1.00
|
F1
|
A:GJ01002
|
0.0
|
71.5
|
1.0
|
C2
|
A:GJ01002
|
1.3
|
71.5
|
1.0
|
C3
|
A:GJ01002
|
2.3
|
71.5
|
1.0
|
C25
|
A:GJ01002
|
2.4
|
71.5
|
1.0
|
F4
|
A:GJ01002
|
2.5
|
71.5
|
1.0
|
CG2
|
A:VAL468
|
2.9
|
87.5
|
1.0
|
N
|
A:VAL468
|
3.0
|
87.5
|
1.0
|
C
|
A:LEU467
|
3.1
|
88.2
|
1.0
|
CB
|
A:LEU467
|
3.2
|
88.2
|
1.0
|
CA
|
A:VAL468
|
3.4
|
87.5
|
1.0
|
O
|
A:LEU467
|
3.5
|
88.2
|
1.0
|
C5
|
A:GJ01002
|
3.6
|
71.5
|
1.0
|
C23
|
A:GJ01002
|
3.6
|
71.5
|
1.0
|
CA
|
A:LEU467
|
3.7
|
88.2
|
1.0
|
CB
|
A:VAL468
|
3.8
|
87.5
|
1.0
|
OH
|
A:TYR404
|
3.8
|
75.7
|
1.0
|
O
|
A:ILE464
|
3.8
|
86.7
|
1.0
|
C6
|
A:GJ01002
|
4.1
|
71.5
|
1.0
|
OD2
|
A:ASP471
|
4.3
|
89.5
|
1.0
|
CG
|
A:LEU467
|
4.4
|
88.2
|
1.0
|
CD2
|
A:LEU467
|
4.4
|
88.2
|
1.0
|
CD1
|
A:LEU447
|
4.5
|
74.6
|
1.0
|
CG1
|
A:ILE464
|
4.5
|
86.7
|
1.0
|
CG
|
A:ASP471
|
4.6
|
89.5
|
1.0
|
N
|
A:LEU467
|
4.6
|
88.2
|
1.0
|
CG1
|
A:VAL468
|
4.7
|
87.5
|
1.0
|
CB
|
A:ASP471
|
4.7
|
89.5
|
1.0
|
C
|
A:VAL468
|
4.8
|
87.5
|
1.0
|
|
Fluorine binding site 2 out
of 6 in 9jvw
Go back to
Fluorine Binding Sites List in 9jvw
Fluorine binding site 2 out
of 6 in the Overall Structure of Human EAAT2 Bound with Inhibitor (Way-213613)
 Mono view
 Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Overall Structure of Human EAAT2 Bound with Inhibitor (Way-213613) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F1002
b:71.5
occ:1.00
|
F4
|
A:GJ01002
|
0.0
|
71.5
|
1.0
|
C3
|
A:GJ01002
|
1.4
|
71.5
|
1.0
|
C2
|
A:GJ01002
|
2.3
|
71.5
|
1.0
|
C5
|
A:GJ01002
|
2.4
|
71.5
|
1.0
|
F1
|
A:GJ01002
|
2.5
|
71.5
|
1.0
|
CG
|
A:MET450
|
2.8
|
75.6
|
1.0
|
OH
|
A:TYR404
|
3.2
|
75.7
|
1.0
|
C25
|
A:GJ01002
|
3.6
|
71.5
|
1.0
|
C6
|
A:GJ01002
|
3.7
|
71.5
|
1.0
|
SD
|
A:MET450
|
3.7
|
75.6
|
1.0
|
CB
|
A:MET450
|
3.8
|
75.6
|
1.0
|
CD2
|
A:LEU467
|
3.8
|
88.2
|
1.0
|
CE
|
A:MET450
|
4.0
|
75.6
|
1.0
|
CB
|
A:LEU467
|
4.1
|
88.2
|
1.0
|
C23
|
A:GJ01002
|
4.1
|
71.5
|
1.0
|
CZ
|
A:TYR404
|
4.2
|
75.7
|
1.0
|
CG1
|
A:ILE464
|
4.2
|
86.7
|
1.0
|
CD1
|
A:ILE464
|
4.4
|
86.7
|
1.0
|
CE2
|
A:TYR404
|
4.5
|
75.7
|
1.0
|
CG
|
A:LEU467
|
4.5
|
88.2
|
1.0
|
CD1
|
A:LEU447
|
4.7
|
74.6
|
1.0
|
O7
|
A:GJ01002
|
4.9
|
71.5
|
1.0
|
O
|
A:GLY446
|
4.9
|
81.2
|
1.0
|
|
Fluorine binding site 3 out
of 6 in 9jvw
Go back to
Fluorine Binding Sites List in 9jvw
Fluorine binding site 3 out
of 6 in the Overall Structure of Human EAAT2 Bound with Inhibitor (Way-213613)
 Mono view
 Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Overall Structure of Human EAAT2 Bound with Inhibitor (Way-213613) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F1002
b:71.5
occ:1.00
|
F1
|
B:GJ01002
|
0.0
|
71.5
|
1.0
|
C2
|
B:GJ01002
|
1.3
|
71.5
|
1.0
|
C3
|
B:GJ01002
|
2.3
|
71.5
|
1.0
|
C25
|
B:GJ01002
|
2.4
|
71.5
|
1.0
|
F4
|
B:GJ01002
|
2.5
|
71.5
|
1.0
|
CG2
|
B:VAL468
|
2.9
|
87.5
|
1.0
|
N
|
B:VAL468
|
3.0
|
87.5
|
1.0
|
C
|
B:LEU467
|
3.1
|
88.2
|
1.0
|
CB
|
B:LEU467
|
3.2
|
88.2
|
1.0
|
CA
|
B:VAL468
|
3.4
|
87.5
|
1.0
|
O
|
B:LEU467
|
3.5
|
88.2
|
1.0
|
C5
|
B:GJ01002
|
3.6
|
71.5
|
1.0
|
C23
|
B:GJ01002
|
3.6
|
71.5
|
1.0
|
CA
|
B:LEU467
|
3.7
|
88.2
|
1.0
|
CB
|
B:VAL468
|
3.8
|
87.5
|
1.0
|
OH
|
B:TYR404
|
3.8
|
75.7
|
1.0
|
O
|
B:ILE464
|
3.8
|
86.7
|
1.0
|
C6
|
B:GJ01002
|
4.1
|
71.5
|
1.0
|
OD2
|
B:ASP471
|
4.3
|
89.5
|
1.0
|
CG
|
B:LEU467
|
4.4
|
88.2
|
1.0
|
CD2
|
B:LEU467
|
4.4
|
88.2
|
1.0
|
CD1
|
B:LEU447
|
4.5
|
74.6
|
1.0
|
CG1
|
B:ILE464
|
4.5
|
86.7
|
1.0
|
N
|
B:LEU467
|
4.6
|
88.2
|
1.0
|
CG
|
B:ASP471
|
4.6
|
89.5
|
1.0
|
CG1
|
B:VAL468
|
4.7
|
87.5
|
1.0
|
CB
|
B:ASP471
|
4.7
|
89.5
|
1.0
|
C
|
B:VAL468
|
4.8
|
87.5
|
1.0
|
|
Fluorine binding site 4 out
of 6 in 9jvw
Go back to
Fluorine Binding Sites List in 9jvw
Fluorine binding site 4 out
of 6 in the Overall Structure of Human EAAT2 Bound with Inhibitor (Way-213613)
 Mono view
 Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Overall Structure of Human EAAT2 Bound with Inhibitor (Way-213613) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F1002
b:71.5
occ:1.00
|
F4
|
B:GJ01002
|
0.0
|
71.5
|
1.0
|
C3
|
B:GJ01002
|
1.4
|
71.5
|
1.0
|
C2
|
B:GJ01002
|
2.3
|
71.5
|
1.0
|
C5
|
B:GJ01002
|
2.4
|
71.5
|
1.0
|
F1
|
B:GJ01002
|
2.5
|
71.5
|
1.0
|
CG
|
B:MET450
|
2.8
|
75.6
|
1.0
|
OH
|
B:TYR404
|
3.2
|
75.7
|
1.0
|
C25
|
B:GJ01002
|
3.6
|
71.5
|
1.0
|
C6
|
B:GJ01002
|
3.7
|
71.5
|
1.0
|
SD
|
B:MET450
|
3.7
|
75.6
|
1.0
|
CB
|
B:MET450
|
3.8
|
75.6
|
1.0
|
CD2
|
B:LEU467
|
3.8
|
88.2
|
1.0
|
CE
|
B:MET450
|
4.0
|
75.6
|
1.0
|
CB
|
B:LEU467
|
4.1
|
88.2
|
1.0
|
C23
|
B:GJ01002
|
4.1
|
71.5
|
1.0
|
CZ
|
B:TYR404
|
4.2
|
75.7
|
1.0
|
CG1
|
B:ILE464
|
4.2
|
86.7
|
1.0
|
CD1
|
B:ILE464
|
4.4
|
86.7
|
1.0
|
CE2
|
B:TYR404
|
4.5
|
75.7
|
1.0
|
CG
|
B:LEU467
|
4.5
|
88.2
|
1.0
|
CD1
|
B:LEU447
|
4.7
|
74.6
|
1.0
|
O7
|
B:GJ01002
|
4.9
|
71.5
|
1.0
|
O
|
B:GLY446
|
4.9
|
81.2
|
1.0
|
|
Fluorine binding site 5 out
of 6 in 9jvw
Go back to
Fluorine Binding Sites List in 9jvw
Fluorine binding site 5 out
of 6 in the Overall Structure of Human EAAT2 Bound with Inhibitor (Way-213613)
 Mono view
 Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Overall Structure of Human EAAT2 Bound with Inhibitor (Way-213613) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:F1002
b:71.5
occ:1.00
|
F1
|
C:GJ01002
|
0.0
|
71.5
|
1.0
|
C2
|
C:GJ01002
|
1.3
|
71.5
|
1.0
|
C3
|
C:GJ01002
|
2.3
|
71.5
|
1.0
|
C25
|
C:GJ01002
|
2.4
|
71.5
|
1.0
|
F4
|
C:GJ01002
|
2.5
|
71.5
|
1.0
|
CG2
|
C:VAL468
|
2.9
|
87.5
|
1.0
|
N
|
C:VAL468
|
3.0
|
87.5
|
1.0
|
C
|
C:LEU467
|
3.1
|
88.2
|
1.0
|
CB
|
C:LEU467
|
3.2
|
88.2
|
1.0
|
CA
|
C:VAL468
|
3.4
|
87.5
|
1.0
|
O
|
C:LEU467
|
3.5
|
88.2
|
1.0
|
C5
|
C:GJ01002
|
3.6
|
71.5
|
1.0
|
C23
|
C:GJ01002
|
3.6
|
71.5
|
1.0
|
CA
|
C:LEU467
|
3.7
|
88.2
|
1.0
|
CB
|
C:VAL468
|
3.8
|
87.5
|
1.0
|
OH
|
C:TYR404
|
3.8
|
75.7
|
1.0
|
O
|
C:ILE464
|
3.8
|
86.7
|
1.0
|
C6
|
C:GJ01002
|
4.1
|
71.5
|
1.0
|
OD2
|
C:ASP471
|
4.3
|
89.5
|
1.0
|
CG
|
C:LEU467
|
4.4
|
88.2
|
1.0
|
CD2
|
C:LEU467
|
4.4
|
88.2
|
1.0
|
CD1
|
C:LEU447
|
4.5
|
74.6
|
1.0
|
CG1
|
C:ILE464
|
4.5
|
86.7
|
1.0
|
CG
|
C:ASP471
|
4.6
|
89.5
|
1.0
|
N
|
C:LEU467
|
4.6
|
88.2
|
1.0
|
CG1
|
C:VAL468
|
4.7
|
87.5
|
1.0
|
CB
|
C:ASP471
|
4.7
|
89.5
|
1.0
|
C
|
C:VAL468
|
4.8
|
87.5
|
1.0
|
|
Fluorine binding site 6 out
of 6 in 9jvw
Go back to
Fluorine Binding Sites List in 9jvw
Fluorine binding site 6 out
of 6 in the Overall Structure of Human EAAT2 Bound with Inhibitor (Way-213613)
 Mono view
 Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Overall Structure of Human EAAT2 Bound with Inhibitor (Way-213613) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:F1002
b:71.5
occ:1.00
|
F4
|
C:GJ01002
|
0.0
|
71.5
|
1.0
|
C3
|
C:GJ01002
|
1.4
|
71.5
|
1.0
|
C2
|
C:GJ01002
|
2.3
|
71.5
|
1.0
|
C5
|
C:GJ01002
|
2.4
|
71.5
|
1.0
|
F1
|
C:GJ01002
|
2.5
|
71.5
|
1.0
|
CG
|
C:MET450
|
2.8
|
75.6
|
1.0
|
OH
|
C:TYR404
|
3.2
|
75.7
|
1.0
|
C25
|
C:GJ01002
|
3.6
|
71.5
|
1.0
|
C6
|
C:GJ01002
|
3.7
|
71.5
|
1.0
|
SD
|
C:MET450
|
3.7
|
75.6
|
1.0
|
CB
|
C:MET450
|
3.8
|
75.6
|
1.0
|
CD2
|
C:LEU467
|
3.8
|
88.2
|
1.0
|
CE
|
C:MET450
|
4.0
|
75.6
|
1.0
|
CB
|
C:LEU467
|
4.1
|
88.2
|
1.0
|
C23
|
C:GJ01002
|
4.1
|
71.5
|
1.0
|
CZ
|
C:TYR404
|
4.2
|
75.7
|
1.0
|
CG1
|
C:ILE464
|
4.2
|
86.7
|
1.0
|
CD1
|
C:ILE464
|
4.4
|
86.7
|
1.0
|
CE2
|
C:TYR404
|
4.5
|
75.7
|
1.0
|
CG
|
C:LEU467
|
4.5
|
88.2
|
1.0
|
CD1
|
C:LEU447
|
4.7
|
74.6
|
1.0
|
O7
|
C:GJ01002
|
4.9
|
71.5
|
1.0
|
O
|
C:GLY446
|
4.9
|
81.2
|
1.0
|
|
Reference:
L.Y.Xia,
Y.Y.Zhang,
Y.Shi,
J.Huang,
Q.Zhou.
Structural Study of Human Glutamate Transporter EAAT2 Dian Zi Xian Wei Xue Bao 2025.
ISSN: ISSN 1000-6281
Page generated: Wed Jul 16 11:45:01 2025
|