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Atomistry » Fluorine » PDB 3sb0-3sym » 3sff » |
Fluorine in PDB 3sff: Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived InhibitorEnzymatic activity of Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor
All present enzymatic activity of Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor:
3.5.1.98; Protein crystallography data
The structure of Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor, PDB code: 3sff
was solved by
T.Stams,
B.Vash,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3sff:
The structure of Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor
(pdb code 3sff). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor, PDB code: 3sff: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 3sffGo back to Fluorine Binding Sites List in 3sff
Fluorine binding site 1 out
of 2 in the Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 3sffGo back to Fluorine Binding Sites List in 3sff
Fluorine binding site 2 out
of 2 in the Crystal Structure of Human HDAC8 Inhibitor Complex, An Amino Acid Derived Inhibitor
Mono view Stereo pair view
Reference:
L.Whitehead,
M.R.Dobler,
B.Radetich,
Y.Zhu,
P.W.Atadja,
T.Claiborne,
J.E.Grob,
A.Mcriner,
M.R.Pancost,
A.Patnaik,
W.Shao,
M.Shultz,
R.Tichkule,
R.A.Tommasi,
B.Vash,
P.Wang,
T.Stams.
Human Hdac Isoform Selectivity Achieved Via Exploitation of the Acetate Release Channel with Structurally Unique Small Molecule Inhibitors. Bioorg.Med.Chem. V. 19 4626 2011.
Page generated: Sun Dec 13 11:55:11 2020
ISSN: ISSN 0968-0896 PubMed: 21723733 DOI: 10.1016/J.BMC.2011.06.030 |
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