Fluorine »
PDB 3wyl-460d »
3zns »
Fluorine in PDB 3zns: HDAC7 Bound with Tfmo Inhibitor TMP942
Enzymatic activity of HDAC7 Bound with Tfmo Inhibitor TMP942
All present enzymatic activity of HDAC7 Bound with Tfmo Inhibitor TMP942:
3.5.1.98;
3.5.1.98;
Protein crystallography data
The structure of HDAC7 Bound with Tfmo Inhibitor TMP942, PDB code: 3zns
was solved by
M.Lobera,
K.P.Madauss,
D.T.Pohlhaus,
R.P.Trump,
M.A.Nolan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 70.71 / 2.45 |
| Space group | P 32 |
| Cell size a, b, c (Å), α, β, γ (°) | 81.570, 81.570, 150.101, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 18.619 / 22.496 |
Other elements in 3zns:
The structure of HDAC7 Bound with Tfmo Inhibitor TMP942 also contains other interesting chemical elements:
| Potassium | (K) | 6 atoms |
| Zinc | (Zn) | 6 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the HDAC7 Bound with Tfmo Inhibitor TMP942
(pdb code 3zns). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 9 binding sites of Fluorine where determined in the HDAC7 Bound with Tfmo Inhibitor TMP942, PDB code: 3zns:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9;
In total 9 binding sites of Fluorine where determined in the HDAC7 Bound with Tfmo Inhibitor TMP942, PDB code: 3zns:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9;
Fluorine binding site 1 out of 9 in 3zns
Go back to
Fluorine Binding Sites List in 3zns
Fluorine binding site 1 out
of 9 in the HDAC7 Bound with Tfmo Inhibitor TMP942
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of HDAC7 Bound with Tfmo Inhibitor TMP942 within 5.0Å range:
|
Fluorine binding site 2 out of 9 in 3zns
Go back to
Fluorine Binding Sites List in 3zns
Fluorine binding site 2 out
of 9 in the HDAC7 Bound with Tfmo Inhibitor TMP942
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of HDAC7 Bound with Tfmo Inhibitor TMP942 within 5.0Å range:
|
Fluorine binding site 3 out of 9 in 3zns
Go back to
Fluorine Binding Sites List in 3zns
Fluorine binding site 3 out
of 9 in the HDAC7 Bound with Tfmo Inhibitor TMP942
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of HDAC7 Bound with Tfmo Inhibitor TMP942 within 5.0Å range:
|
Fluorine binding site 4 out of 9 in 3zns
Go back to
Fluorine Binding Sites List in 3zns
Fluorine binding site 4 out
of 9 in the HDAC7 Bound with Tfmo Inhibitor TMP942
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of HDAC7 Bound with Tfmo Inhibitor TMP942 within 5.0Å range:
|
Fluorine binding site 5 out of 9 in 3zns
Go back to
Fluorine Binding Sites List in 3zns
Fluorine binding site 5 out
of 9 in the HDAC7 Bound with Tfmo Inhibitor TMP942
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of HDAC7 Bound with Tfmo Inhibitor TMP942 within 5.0Å range:
|
Fluorine binding site 6 out of 9 in 3zns
Go back to
Fluorine Binding Sites List in 3zns
Fluorine binding site 6 out
of 9 in the HDAC7 Bound with Tfmo Inhibitor TMP942
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of HDAC7 Bound with Tfmo Inhibitor TMP942 within 5.0Å range:
|
Fluorine binding site 7 out of 9 in 3zns
Go back to
Fluorine Binding Sites List in 3zns
Fluorine binding site 7 out
of 9 in the HDAC7 Bound with Tfmo Inhibitor TMP942
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 7 of HDAC7 Bound with Tfmo Inhibitor TMP942 within 5.0Å range:
|
Fluorine binding site 8 out of 9 in 3zns
Go back to
Fluorine Binding Sites List in 3zns
Fluorine binding site 8 out
of 9 in the HDAC7 Bound with Tfmo Inhibitor TMP942
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 8 of HDAC7 Bound with Tfmo Inhibitor TMP942 within 5.0Å range:
|
Fluorine binding site 9 out of 9 in 3zns
Go back to
Fluorine Binding Sites List in 3zns
Fluorine binding site 9 out
of 9 in the HDAC7 Bound with Tfmo Inhibitor TMP942
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 9 of HDAC7 Bound with Tfmo Inhibitor TMP942 within 5.0Å range:
|
Reference:
M.Lobera,
K.P.Madauss,
D.T.Pohlhaus,
Q.G.Wright,
M.Trocha,
D.R.Schmidt,
E.Baloglu,
R.P.Trump,
M.S.Head,
G.A.Hofmann,
M.Murray-Thompson,
B.Schwartz,
S.Chakravorty,
Z.Wu,
P.K.Mander,
L.Kruidenier,
R.A.Reid,
W.Burkhart,
B.J.Turunen,
J.X.Rong,
C.Wagner,
M.B.Moyer,
C.Wells,
X.Hong,
J.T.Moore,
J.D.Williams,
D.Soler,
S.Ghosh,
M.A.Nolan.
Selective Class Iia Histone Deacetylase Inhibition Via A Non-Chelating Zinc Binding Group Nat.Chem.Biol. V. 9 319 2013.
ISSN: ISSN 1552-4450
PubMed: 23524983
DOI: 10.1038/NCHEMBIO.1223
Page generated: Sun Dec 13 11:58:12 2020
ISSN: ISSN 1552-4450
PubMed: 23524983
DOI: 10.1038/NCHEMBIO.1223
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