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Fluorine in PDB 4asd: Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with Sorafenib (Bay 43-9006)
Enzymatic activity of Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with Sorafenib (Bay 43-9006)
All present enzymatic activity of Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with Sorafenib (Bay 43-9006):
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with Sorafenib (Bay 43-9006), PDB code: 4asd
was solved by
M.Mctigue,
Y.Deng,
K.Ryan,
A.Brooun,
W.Diehl,
A.Stewart,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 15.00 / 2.03 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 135.818, 56.479, 52.052, 90.00, 95.42, 90.00 |
| R / Rfree (%) | 17.5 / 23 |
Other elements in 4asd:
The structure of Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with Sorafenib (Bay 43-9006) also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with Sorafenib (Bay 43-9006)
(pdb code 4asd). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with Sorafenib (Bay 43-9006), PDB code: 4asd:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with Sorafenib (Bay 43-9006), PDB code: 4asd:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 4asd
Go back to
Fluorine Binding Sites List in 4asd
Fluorine binding site 1 out
of 3 in the Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with Sorafenib (Bay 43-9006)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with Sorafenib (Bay 43-9006) within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 4asd
Go back to
Fluorine Binding Sites List in 4asd
Fluorine binding site 2 out
of 3 in the Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with Sorafenib (Bay 43-9006)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with Sorafenib (Bay 43-9006) within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 4asd
Go back to
Fluorine Binding Sites List in 4asd
Fluorine binding site 3 out
of 3 in the Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with Sorafenib (Bay 43-9006)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with Sorafenib (Bay 43-9006) within 5.0Å range:
|
Reference:
M.Mctigue,
B.W.Murray,
J.H.Chen,
Y.Deng,
J.Solowiej,
R.S.Kania.
Molecular Conformations, Interactions, and Properties Associated with Drug Efficiency and Clinical Performance Among Vegfr Tk Inhibitors. Proc.Natl.Acad.Sci.Usa V. 109 18281 2012.
ISSN: ISSN 0027-8424
PubMed: 22988103
DOI: 10.1073/PNAS.1207759109
Page generated: Thu Aug 1 00:03:27 2024
ISSN: ISSN 0027-8424
PubMed: 22988103
DOI: 10.1073/PNAS.1207759109
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