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Atomistry » Fluorine » PDB 4c6l-4cqj » 4cmt » |
Fluorine in PDB 4cmt: Structure of the Human Anaplastic Lymphoma Kinase in Complex with the Inhibitor 3-((1R)-1-(5-Fluoro-2-(2H-1,2,3-Triazol-2-Yl) Phenyl)Ethoxy)-5-(3-(Methylsulfonyl)Phenyl)Pyridin-2-AmineEnzymatic activity of Structure of the Human Anaplastic Lymphoma Kinase in Complex with the Inhibitor 3-((1R)-1-(5-Fluoro-2-(2H-1,2,3-Triazol-2-Yl) Phenyl)Ethoxy)-5-(3-(Methylsulfonyl)Phenyl)Pyridin-2-Amine
All present enzymatic activity of Structure of the Human Anaplastic Lymphoma Kinase in Complex with the Inhibitor 3-((1R)-1-(5-Fluoro-2-(2H-1,2,3-Triazol-2-Yl) Phenyl)Ethoxy)-5-(3-(Methylsulfonyl)Phenyl)Pyridin-2-Amine:
2.7.10.1; Protein crystallography data
The structure of Structure of the Human Anaplastic Lymphoma Kinase in Complex with the Inhibitor 3-((1R)-1-(5-Fluoro-2-(2H-1,2,3-Triazol-2-Yl) Phenyl)Ethoxy)-5-(3-(Methylsulfonyl)Phenyl)Pyridin-2-Amine, PDB code: 4cmt
was solved by
M.A.Mctigue,
Y.L.Deng,
W.Liu,
A.Brooun,
A.E.Stewart,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of the Human Anaplastic Lymphoma Kinase in Complex with the Inhibitor 3-((1R)-1-(5-Fluoro-2-(2H-1,2,3-Triazol-2-Yl) Phenyl)Ethoxy)-5-(3-(Methylsulfonyl)Phenyl)Pyridin-2-Amine
(pdb code 4cmt). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of the Human Anaplastic Lymphoma Kinase in Complex with the Inhibitor 3-((1R)-1-(5-Fluoro-2-(2H-1,2,3-Triazol-2-Yl) Phenyl)Ethoxy)-5-(3-(Methylsulfonyl)Phenyl)Pyridin-2-Amine, PDB code: 4cmt: Fluorine binding site 1 out of 1 in 4cmtGo back to Fluorine Binding Sites List in 4cmt
Fluorine binding site 1 out
of 1 in the Structure of the Human Anaplastic Lymphoma Kinase in Complex with the Inhibitor 3-((1R)-1-(5-Fluoro-2-(2H-1,2,3-Triazol-2-Yl) Phenyl)Ethoxy)-5-(3-(Methylsulfonyl)Phenyl)Pyridin-2-Amine
Mono view Stereo pair view
Reference:
T.W.Johnson,
P.F.Richardson,
S.Bailey,
A.Brooun,
B.J.Burke,
M.R.Collins,
J.J.Cui,
J.G.Deal,
Y.L.Deng,
D.M.Dinh,
L.D.Engstrom,
M.He,
J.E.Hoffman,
R.L.Hoffman,
Q.Huang,
J.Kath,
R.S.Kania,
H.Lam,
J.L.Lam,
P.T.Le,
L.Lingardo,
W.Liu,
M.A.Mctigue,
C.L.Palmer,
N.W.Sach,
T.Smeal,
G.L.Smith,
A.E.Stewart,
S.L.Timofeevski,
H.Zhu,
J.Zhu,
H.Y.Zou,
M.P.Edwards.
Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15- Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3- H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf- 06463922), A Macrocyclic Inhibitor of Alk/ROS1 with Pre- Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations. J.Med.Chem. V. 57 4720 2014.
Page generated: Sun Dec 13 12:00:34 2020
ISSN: ISSN 0022-2623 PubMed: 24819116 DOI: 10.1021/JM500261Q |
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