Fluorine »
PDB 4dbu-4e28 »
4dk8 »
Fluorine in PDB 4dk8: Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5
Enzymatic activity of Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5
All present enzymatic activity of Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5:
2.3.1.48;
2.3.1.48;
Protein crystallography data
The structure of Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5, PDB code: 4dk8
was solved by
D.E.Piper,
D.J.Kopecky,
H.Xu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.73 / 2.75 |
| Space group | P 43 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 88.145, 88.145, 198.450, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 24.5 / 27.8 |
Other elements in 4dk8:
The structure of Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5 also contains other interesting chemical elements:
| Calcium | (Ca) | 6 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5
(pdb code 4dk8). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5, PDB code: 4dk8:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5, PDB code: 4dk8:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 4dk8
Go back to
Fluorine Binding Sites List in 4dk8
Fluorine binding site 1 out
of 6 in the Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5 within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 4dk8
Go back to
Fluorine Binding Sites List in 4dk8
Fluorine binding site 2 out
of 6 in the Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5 within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 4dk8
Go back to
Fluorine Binding Sites List in 4dk8
Fluorine binding site 3 out
of 6 in the Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5 within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 4dk8
Go back to
Fluorine Binding Sites List in 4dk8
Fluorine binding site 4 out
of 6 in the Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5 within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 4dk8
Go back to
Fluorine Binding Sites List in 4dk8
Fluorine binding site 5 out
of 6 in the Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5 within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 4dk8
Go back to
Fluorine Binding Sites List in 4dk8
Fluorine binding site 6 out
of 6 in the Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure of Lxr Ligand Binding Domain in Complex with Partial Agonist 5 within 5.0Å range:
|
Reference:
D.J.Kopecky,
X.Y.Jiao,
B.Fisher,
S.Mckendry,
M.Labelle,
D.E.Piper,
P.Coward,
A.K.Shiau,
P.Escaron,
J.Danao,
A.Chai,
J.Jaen,
F.Kayser.
Discovery of A New Binding Mode For A Series of Liver X Receptor Agonists. Bioorg.Med.Chem.Lett. V. 22 2407 2012.
ISSN: ISSN 0960-894X
PubMed: 22406115
DOI: 10.1016/J.BMCL.2012.02.028
Page generated: Thu Aug 1 01:00:17 2024
ISSN: ISSN 0960-894X
PubMed: 22406115
DOI: 10.1016/J.BMCL.2012.02.028
Last articles
Zn in 9JPJZn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
