Fluorine »
PDB 5btf-5cgq »
5bvn »
Fluorine in PDB 5bvn: Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors
Enzymatic activity of Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors
All present enzymatic activity of Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors, PDB code: 5bvn
was solved by
C.Murray,
V.Berdini,
I.Buck,
M.Carr,
A.Cleasby,
J.Coyle,
J.Curry,
J.Day,
K.Hearn,
A.Iqbal,
L.Lee,
V.Martins,
P.Mortenson,
J.Munck,
L.Page,
S.Patel,
S.Roomans,
T.Kirsten,
G.Saxty,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 31.80 / 2.21 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 61.040, 78.497, 74.499, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 25.2 / 32.8 |
Other elements in 5bvn:
The structure of Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors also contains other interesting chemical elements:
| Iodine | (I) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors
(pdb code 5bvn). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors, PDB code: 5bvn:
In total only one binding site of Fluorine was determined in the Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors, PDB code: 5bvn:
Fluorine binding site 1 out of 1 in 5bvn
Go back to
Fluorine Binding Sites List in 5bvn
Fluorine binding site 1 out
of 1 in the Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors within 5.0Å range:
|
Reference:
C.W.Murray,
V.Berdini,
I.M.Buck,
M.E.Carr,
A.Cleasby,
J.E.Coyle,
J.E.Curry,
J.E.Day,
P.J.Day,
K.Hearn,
A.Iqbal,
L.Y.Lee,
V.Martins,
P.N.Mortenson,
J.M.Munck,
L.W.Page,
S.Patel,
S.Roomans,
K.Smith,
E.Tamanini,
G.Saxty.
Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors. Acs Med.Chem.Lett. V. 6 798 2015.
ISSN: ISSN 1948-5875
PubMed: 26191369
DOI: 10.1021/ACSMEDCHEMLETT.5B00143
Page generated: Sun Dec 13 12:19:49 2020
ISSN: ISSN 1948-5875
PubMed: 26191369
DOI: 10.1021/ACSMEDCHEMLETT.5B00143
Last articles
Zn in 8WB0Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
