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Fluorine in PDB 5wbp: Structure of Human Ketohexokinase Complexed with Hits From Fragment ScreeningEnzymatic activity of Structure of Human Ketohexokinase Complexed with Hits From Fragment Screening
All present enzymatic activity of Structure of Human Ketohexokinase Complexed with Hits From Fragment Screening:
2.7.1.3; Protein crystallography data
The structure of Structure of Human Ketohexokinase Complexed with Hits From Fragment Screening, PDB code: 5wbp
was solved by
J.Pandit,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Human Ketohexokinase Complexed with Hits From Fragment Screening
(pdb code 5wbp). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Structure of Human Ketohexokinase Complexed with Hits From Fragment Screening, PDB code: 5wbp: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 5wbpGo back to Fluorine Binding Sites List in 5wbp
Fluorine binding site 1 out
of 3 in the Structure of Human Ketohexokinase Complexed with Hits From Fragment Screening
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 5wbpGo back to Fluorine Binding Sites List in 5wbp
Fluorine binding site 2 out
of 3 in the Structure of Human Ketohexokinase Complexed with Hits From Fragment Screening
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 5wbpGo back to Fluorine Binding Sites List in 5wbp
Fluorine binding site 3 out
of 3 in the Structure of Human Ketohexokinase Complexed with Hits From Fragment Screening
Mono view Stereo pair view
Reference:
K.Huard,
K.Ahn,
P.Amor,
D.A.Beebe,
K.A.Borzilleri,
B.A.Chrunyk,
S.B.Coffey,
Y.Cong,
E.L.Conn,
J.S.Culp,
M.S.Dowling,
M.F.Gorgoglione,
J.A.Gutierrez,
J.D.Knafels,
E.A.Lachapelle,
J.Pandit,
K.D.Parris,
S.Perez,
J.A.Pfefferkorn,
D.A.Price,
B.Raymer,
T.T.Ross,
A.Shavnya,
A.C.Smith,
T.A.Subashi,
G.J.Tesz,
B.A.Thuma,
M.Tu,
J.D.Weaver,
Y.Weng,
J.M.Withka,
G.Xing,
T.V.Magee.
Discovery of Fragment-Derived Small Molecules For in Vivo Inhibition of Ketohexokinase (Khk). J. Med. Chem. V. 60 7835 2017.
Page generated: Sun Dec 13 12:41:37 2020
ISSN: ISSN 1520-4804 PubMed: 28853885 DOI: 10.1021/ACS.JMEDCHEM.7B00947 |
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