Fluorine in PDB 6maj: HBO1 Is Required For the Maintenance of Leukaemia Stem Cells

All present enzymatic activity of HBO1 Is Required For the Maintenance of Leukaemia Stem Cells:
2.3.1.48;

The structure of HBO1 Is Required For the Maintenance of Leukaemia Stem Cells, PDB code: 6maj was solved by B.Ren, T.S.Peat, B.Monahan, M.Dawson, I.Street, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	58.60 / 2.14
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	111.543, 111.543, 73.702, 90.00, 90.00, 120.00
R / Rfree (%)	19.5 / 23.7

The structure of HBO1 Is Required For the Maintenance of Leukaemia Stem Cells also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Fluorine atom in the HBO1 Is Required For the Maintenance of Leukaemia Stem Cells (pdb code 6maj). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the HBO1 Is Required For the Maintenance of Leukaemia Stem Cells, PDB code: 6maj:

Fluorine binding site 1 out of 1 in the HBO1 Is Required For the Maintenance of Leukaemia Stem Cells


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of HBO1 Is Required For the Maintenance of Leukaemia Stem Cells within 5.0Å range: probe atom residue distance (Å) B Occ A:F704 b:20.8 occ:0.88 F08 A:JAV704 0.0 20.8 0.9 C07 A:JAV704 1.4 20.1 0.9 C02 A:JAV704 2.4 16.9 0.9 C06 A:JAV704 2.4 16.4 0.9 C01 A:JAV704 2.8 15.9 0.9 C09 A:JAV704 2.9 19.0 0.9 N11 A:JAV704 3.0 21.7 0.9 OG A:SER518 3.0 23.1 1.0 CB A:SER518 3.1 22.0 1.0 CA A:GLY487 3.3 19.0 1.0 C A:GLY487 3.5 18.9 1.0 C03 A:JAV704 3.6 14.0 0.9 C05 A:JAV704 3.6 14.8 0.9 O A:GLY487 3.6 20.8 1.0 O10 A:JAV704 3.8 20.3 0.9 CD1 A:ILE491 3.8 18.1 1.0 C17 A:JAV704 3.8 21.6 0.9 C04 A:JAV704 4.1 13.4 0.9 N A:LYS488 4.1 21.1 1.0 N12 A:JAV704 4.2 26.1 0.9 O14 A:JAV704 4.3 27.4 0.9 CG1 A:ILE491 4.3 18.1 1.0 N A:GLY487 4.5 26.1 1.0 CA A:SER518 4.6 21.5 1.0 S13 A:JAV704 4.6 27.1 0.9 C18 A:JAV704 4.7 23.1 0.9 C16 A:JAV704 4.7 25.8 0.9 CG2 A:THR477 4.7 30.6 1.0

L.Macpherson, J.Anokye, M.M.Yeung, E.Y.N.Lam, Y.C.Chan, C.F.Weng, P.Yeh, K.Knezevic, M.S.Butler, A.Hoegl, K.L.Chan, M.L.Burr, L.J.Gearing, T.Willson, J.Liu, J.Choi, Y.Yang, R.A.Bilardi, H.Falk, N.Nguyen, P.A.Stupple, T.S.Peat, M.Zhang, M.De Silva, C.Carrasco-Pozo, V.M.Avery, P.S.Khoo, O.Dolezal, M.L.Dennis, S.Nuttall, R.Surjadi, J.Newman, B.Ren, D.J.Leaver, Y.Sun, J.B.Baell, O.Dovey, G.S.Vassiliou, F.Grebien, S.J.Dawson, I.P.Street, B.J.Monahan, C.J.Burns, C.Choudhary, M.E.Blewitt, A.K.Voss, T.Thomas, M.A.Dawson. HBO1 Is Required For the Maintenance of Leukaemia Stem Cells. Nature 2019.
ISSN: ESSN 1476-4687
PubMed: 31827282
DOI: 10.1038/S41586-019-1835-6