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Fluorine in PDB 6txp: Human Aldose Reductase Mutant L300A in Complex with A Ligand with An Idd Structure (3-({[2-(Carboxymethoxy)-4-Fluorobenzoyl]Amino}Methyl) Benzoic Acid)
Enzymatic activity of Human Aldose Reductase Mutant L300A in Complex with A Ligand with An Idd Structure (3-({[2-(Carboxymethoxy)-4-Fluorobenzoyl]Amino}Methyl) Benzoic Acid)
All present enzymatic activity of Human Aldose Reductase Mutant L300A in Complex with A Ligand with An Idd Structure (3-({[2-(Carboxymethoxy)-4-Fluorobenzoyl]Amino}Methyl) Benzoic Acid):
1.1.1.21; 1.1.1.300; 1.1.1.372; 1.1.1.54;
1.1.1.21; 1.1.1.300; 1.1.1.372; 1.1.1.54;
Protein crystallography data
The structure of Human Aldose Reductase Mutant L300A in Complex with A Ligand with An Idd Structure (3-({[2-(Carboxymethoxy)-4-Fluorobenzoyl]Amino}Methyl) Benzoic Acid), PDB code: 6txp
was solved by
L.-S.Hubert,
M.Ley,
A.Heine,
G.Klebe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 33.43 / 0.95 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 47.314, 66.899, 49.232, 90, 92.26, 90 |
| R / Rfree (%) | 11.5 / 12.7 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Aldose Reductase Mutant L300A in Complex with A Ligand with An Idd Structure (3-({[2-(Carboxymethoxy)-4-Fluorobenzoyl]Amino}Methyl) Benzoic Acid)
(pdb code 6txp). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Human Aldose Reductase Mutant L300A in Complex with A Ligand with An Idd Structure (3-({[2-(Carboxymethoxy)-4-Fluorobenzoyl]Amino}Methyl) Benzoic Acid), PDB code: 6txp:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Human Aldose Reductase Mutant L300A in Complex with A Ligand with An Idd Structure (3-({[2-(Carboxymethoxy)-4-Fluorobenzoyl]Amino}Methyl) Benzoic Acid), PDB code: 6txp:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 6txp
Go back to
Fluorine Binding Sites List in 6txp
Fluorine binding site 1 out
of 3 in the Human Aldose Reductase Mutant L300A in Complex with A Ligand with An Idd Structure (3-({[2-(Carboxymethoxy)-4-Fluorobenzoyl]Amino}Methyl) Benzoic Acid)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Human Aldose Reductase Mutant L300A in Complex with A Ligand with An Idd Structure (3-({[2-(Carboxymethoxy)-4-Fluorobenzoyl]Amino}Methyl) Benzoic Acid) within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 6txp
Go back to
Fluorine Binding Sites List in 6txp
Fluorine binding site 2 out
of 3 in the Human Aldose Reductase Mutant L300A in Complex with A Ligand with An Idd Structure (3-({[2-(Carboxymethoxy)-4-Fluorobenzoyl]Amino}Methyl) Benzoic Acid)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Human Aldose Reductase Mutant L300A in Complex with A Ligand with An Idd Structure (3-({[2-(Carboxymethoxy)-4-Fluorobenzoyl]Amino}Methyl) Benzoic Acid) within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 6txp
Go back to
Fluorine Binding Sites List in 6txp
Fluorine binding site 3 out
of 3 in the Human Aldose Reductase Mutant L300A in Complex with A Ligand with An Idd Structure (3-({[2-(Carboxymethoxy)-4-Fluorobenzoyl]Amino}Methyl) Benzoic Acid)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Human Aldose Reductase Mutant L300A in Complex with A Ligand with An Idd Structure (3-({[2-(Carboxymethoxy)-4-Fluorobenzoyl]Amino}Methyl) Benzoic Acid) within 5.0Å range:
|
Reference:
L.-S.Hubert,
M.Ley,
F.Scheer,
W.Diederich,
A.Heine,
G.Klebe.
Human Aldose Reductase Mutant L300A in Complex with A Ligand with An Idd Structure (3-({[2-(Carboxymethoxy)-4-Fluorobenzoyl]Amino}Methyl) Benzoic Acid) To Be Published.
Page generated: Fri Aug 2 02:16:31 2024
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