Fluorine in PDB 6v3w: Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397
Protein crystallography data
The structure of Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397, PDB code: 6v3w
was solved by
K.K.Swinger,
J.M.Gozgit,
M.M.Vasbinder,
T.J.Wigle,
K.W.Kuntz,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 69.78 / 2.04 |
| Space group | P 65 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 80.466, 80.466, 142.648, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 21 / 25.5 |
Other elements in 6v3w:
The structure of Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397 also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397
(pdb code 6v3w). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397, PDB code: 6v3w:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397, PDB code: 6v3w:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 6v3w
Go back to
Fluorine Binding Sites List in 6v3w
Fluorine binding site 1 out
of 6 in the Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397 within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 6v3w
Go back to
Fluorine Binding Sites List in 6v3w
Fluorine binding site 2 out
of 6 in the Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397 within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 6v3w
Go back to
Fluorine Binding Sites List in 6v3w
Fluorine binding site 3 out
of 6 in the Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397 within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 6v3w
Go back to
Fluorine Binding Sites List in 6v3w
Fluorine binding site 4 out
of 6 in the Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397 within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 6v3w
Go back to
Fluorine Binding Sites List in 6v3w
Fluorine binding site 5 out
of 6 in the Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397 within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 6v3w
Go back to
Fluorine Binding Sites List in 6v3w
Fluorine binding site 6 out
of 6 in the Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Human Poly(Adp-Ribose) Polymerase 12, Catalytic Fragment with Four Point Mutations in Complex with Rbn-2397 within 5.0Å range:
|
Reference:
J.M.Gozgit,
M.M.Vasbinder,
R.Abo,
K.Kunii,
K.Kuplast-Barr,
B.Gui,
A.Lu,
K.K.Swinger,
T.J.Wigle,
D.Blackwell,
C.R.Majer,
Y.Ren,
M.Niepel,
Z.Varsamis,
S.Nayak,
E.Bamberg,
J.Mo,
W.D.Church,
J.Song,
L.Utley,
K.W.Kuntz,
V.Richon,
H.Keilhack.
PARP7 Negatively Regulates the Type I Interferon Response in Cancer Cells, and Its Inhibition Triggers Antitumor Immunity To Be Published.
Page generated: Thu Dec 17 11:17:20 2020
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