Fluorine in PDB 7g8c: ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1037511924

All present enzymatic activity of ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1037511924:
3.6.5.2;

The structure of ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1037511924, PDB code: 7g8c was solved by W.J.Bradshaw, V.L.Katis, C.Bountra, F.Von Delft, P.E.Brennan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	67.42 / 2.18
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	71.758, 71.758, 196.96, 90, 90, 90
R / Rfree (%)	20.2 / 25.5

The binding sites of Fluorine atom in the ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1037511924 (pdb code 7g8c). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1037511924, PDB code: 7g8c:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1037511924


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1037511924 within 5.0Å range: probe atom residue distance (Å) B Occ A:F201 b:71.4 occ:0.86 F12 A:YXO201 0.0 71.4 0.9 C11 A:YXO201 1.4 71.5 0.9 F13 A:YXO201 2.3 71.5 0.9 N06 A:YXO201 2.4 71.4 0.9 C07 A:YXO201 2.8 71.3 0.9 C05 A:YXO201 3.7 71.3 0.9 CE2 A:PHE106 3.7 37.0 1.0 OE1 A:GLU102 4.0 51.4 1.0 CZ A:PHE106 4.1 37.1 1.0 C08 A:YXO201 4.1 71.2 0.9 O A:ASP67 4.4 40.7 1.0 CD A:GLU102 4.4 47.7 1.0 CG A:GLU102 4.4 41.7 1.0 O A:HOH386 4.4 64.4 1.0 C04 A:YXO201 4.5 71.4 0.9 C09 A:YXO201 4.5 71.3 0.9 NH2 A:ARG70 4.7 38.3 1.0 CB A:ASP67 4.8 42.0 1.0 CG A:PRO71 4.8 35.1 1.0 CD2 A:PHE106 4.8 36.4 1.0

Fluorine binding site 2 out of 2 in the ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1037511924


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1037511924 within 5.0Å range: probe atom residue distance (Å) B Occ A:F201 b:71.5 occ:0.86 F13 A:YXO201 0.0 71.5 0.9 C11 A:YXO201 1.4 71.5 0.9 F12 A:YXO201 2.3 71.4 0.9 N06 A:YXO201 2.4 71.4 0.9 C05 A:YXO201 3.0 71.3 0.9 C04 A:YXO201 3.2 71.4 0.9 C07 A:YXO201 3.6 71.3 0.9 O A:HOH386 3.7 64.4 1.0 CZ A:PHE106 4.2 37.1 1.0 C09 A:YXO201 4.3 71.3 0.9 CE2 A:PHE106 4.4 37.0 1.0 C03 A:YXO201 4.5 71.4 0.9 C08 A:YXO201 4.6 71.2 0.9

W.J.Bradshaw, V.L.Katis, C.Bountra, F.Von Delft, P.E.Brennan. ARHGEF2 Pandda Analysis Group Deposition To Be Published.