Fluorine in PDB 7g8i: ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1198316457

All present enzymatic activity of ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1198316457:
3.6.5.2;

The structure of ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1198316457, PDB code: 7g8i was solved by W.J.Bradshaw, V.L.Katis, C.Bountra, F.Von Delft, P.E.Brennan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.65 / 2.47
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	70.966, 70.966, 195.747, 90, 90, 90
R / Rfree (%)	20.9 / 27.3

The binding sites of Fluorine atom in the ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1198316457 (pdb code 7g8i). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1198316457, PDB code: 7g8i:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1198316457


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1198316457 within 5.0Å range: probe atom residue distance (Å) B Occ A:F201 b:78.2 occ:0.80 F08 A:YXY201 0.0 78.2 0.8 C07 A:YXY201 1.4 78.4 0.8 F09 A:YXY201 2.2 78.9 0.8 C10 A:YXY201 2.4 78.2 0.8 C06 A:YXY201 2.4 77.9 0.8 C11 A:YXY201 2.9 77.7 0.8 C05 A:YXY201 3.1 77.4 0.8 C04 A:YXY201 3.3 77.0 0.8 CG2 A:VAL33 4.7 60.3 1.0 C02 A:YXY201 4.8 76.0 0.8

Fluorine binding site 2 out of 2 in the ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1198316457


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of ARHGEF2 Pandda Analysis Group Deposition -- ARHGEF2 and Rhoa in Complex with Z1198316457 within 5.0Å range: probe atom residue distance (Å) B Occ A:F201 b:78.9 occ:0.80 F09 A:YXY201 0.0 78.9 0.8 C07 A:YXY201 1.4 78.4 0.8 F08 A:YXY201 2.2 78.2 0.8 C06 A:YXY201 2.3 77.9 0.8 C10 A:YXY201 2.4 78.2 0.8 C11 A:YXY201 3.7 77.7 0.8 C05 A:YXY201 3.7 77.4 0.8 C04 A:YXY201 4.3 77.0 0.8 CG A:GLN29 4.4 81.3 1.0

W.J.Bradshaw, V.L.Katis, C.Bountra, F.Von Delft, P.E.Brennan. ARHGEF2 Pandda Analysis Group Deposition To Be Published.