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Fluorine in PDB 1c9d: Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid
Enzymatic activity of Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid
All present enzymatic activity of Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid:
4.2.1.20;
4.2.1.20;
Protein crystallography data
The structure of Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid, PDB code: 1c9d
was solved by
E.Lolis,
A.Sachpatzidis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 30.00 / 2.30 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 184.220, 60.520, 67.790, 90.00, 94.43, 90.00 |
| R / Rfree (%) | 21.1 / 26.9 |
Other elements in 1c9d:
The structure of Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid also contains other interesting chemical elements:
| Sodium | (Na) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid
(pdb code 1c9d). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid, PDB code: 1c9d:
In total only one binding site of Fluorine was determined in the Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid, PDB code: 1c9d:
Fluorine binding site 1 out of 1 in 1c9d
Go back to
Fluorine Binding Sites List in 1c9d
Fluorine binding site 1 out
of 1 in the Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the Complex of Bacterial Tryptophan Synthase with the Transition State Analogue Inhibitor 4-(2-Hydroxy-4- Fluorophenylthio)-Butylphosphonic Acid within 5.0Å range:
|
Reference:
A.Sachpatzidis,
C.Dealwis,
J.B.Lubetsky,
P.H.Liang,
K.S.Anderson,
E.Lolis.
Crystallographic Studies of Phosphonate-Based Alpha-Reaction Transition-State Analogues Complexed to Tryptophan Synthase. Biochemistry V. 38 12665 1999.
ISSN: ISSN 0006-2960
PubMed: 10504236
DOI: 10.1021/BI9907734
Page generated: Sun Dec 13 11:28:39 2020
ISSN: ISSN 0006-2960
PubMed: 10504236
DOI: 10.1021/BI9907734
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