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Fluorine in PDB 4qwe: Ternary Crystal Structures of A Y-Family Dna Polymerase DPO4 From Sulfolobus Solfataricus in Complex with Dna and (-)Ftc-Dp

Enzymatic activity of Ternary Crystal Structures of A Y-Family Dna Polymerase DPO4 From Sulfolobus Solfataricus in Complex with Dna and (-)Ftc-Dp

All present enzymatic activity of Ternary Crystal Structures of A Y-Family Dna Polymerase DPO4 From Sulfolobus Solfataricus in Complex with Dna and (-)Ftc-Dp:
2.7.7.7;

Protein crystallography data

The structure of Ternary Crystal Structures of A Y-Family Dna Polymerase DPO4 From Sulfolobus Solfataricus in Complex with Dna and (-)Ftc-Dp, PDB code: 4qwe was solved by V.Gaur, Z.Suo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.73 / 2.20
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 96.698, 102.432, 52.460, 90.00, 90.00, 90.00
R / Rfree (%) 21.5 / 25.1

Other elements in 4qwe:

The structure of Ternary Crystal Structures of A Y-Family Dna Polymerase DPO4 From Sulfolobus Solfataricus in Complex with Dna and (-)Ftc-Dp also contains other interesting chemical elements:

Calcium (Ca) 3 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Ternary Crystal Structures of A Y-Family Dna Polymerase DPO4 From Sulfolobus Solfataricus in Complex with Dna and (-)Ftc-Dp (pdb code 4qwe). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Ternary Crystal Structures of A Y-Family Dna Polymerase DPO4 From Sulfolobus Solfataricus in Complex with Dna and (-)Ftc-Dp, PDB code: 4qwe:

Fluorine binding site 1 out of 1 in 4qwe

Go back to Fluorine Binding Sites List in 4qwe
Fluorine binding site 1 out of 1 in the Ternary Crystal Structures of A Y-Family Dna Polymerase DPO4 From Sulfolobus Solfataricus in Complex with Dna and (-)Ftc-Dp


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Ternary Crystal Structures of A Y-Family Dna Polymerase DPO4 From Sulfolobus Solfataricus in Complex with Dna and (-)Ftc-Dp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F701

b:72.4
occ:1.00
 F5 A:FTD701 0.0 72.4 1.0
C5 A:FTD701 1.3 66.0 1.0
C6 A:FTD701 2.3 65.1 1.0
C4 A:FTD701 2.3 64.1 1.0
N4 A:FTD701 2.7 67.0 1.0
O A:HOH820 2.8 52.7 1.0
O C:HOH115 3.2 54.9 1.0
CB A:ALA57 3.3 43.7 1.0
C5 C:DC13 3.4 45.6 1.0
N3 A:FTD701 3.6 62.5 1.0
N1 A:FTD701 3.6 65.5 1.0
C6 C:DC13 3.6 49.0 1.0
C4 C:DC13 3.7 44.0 1.0
N1 C:DC13 4.0 58.6 1.0
C2 A:FTD701 4.1 61.7 1.0
N3 C:DC13 4.2 43.8 1.0
N4 C:DC13 4.3 40.7 1.0
C2 C:DC13 4.3 48.8 1.0
O A:ALA44 4.5 29.4 1.0
C2' C:DC13 4.6 78.8 1.0
O A:HOH974 4.8 66.8 1.0
C1' A:FTD701 4.8 71.1 1.0
O C:HOH106 4.8 71.6 1.0
CA A:ALA57 4.9 43.1 1.0
C1' C:DC13 4.9 71.0 1.0
O4' A:FTD701 4.9 73.5 1.0

Reference:

V.Gaur, R.Vyas, J.D.Fowler, G.Efthimiopoulos, J.Y.Feng, Z.Suo. Structural and Kinetic Insights Into Binding and Incorporation of L-Nucleotide Analogs By A Y-Family Dna Polymerase. Nucleic Acids Res. V. 42 9984 2014.
ISSN: ISSN 0305-1048
PubMed: 25104018
DOI: 10.1093/NAR/GKU709
Page generated: Thu Aug 1 05:30:55 2024

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