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Atomistry » Fluorine » PDB 4qte-4rv6 » 4r3c » |
Fluorine in PDB 4r3c: Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug CandidateEnzymatic activity of Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug Candidate
All present enzymatic activity of Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug Candidate:
2.7.11.24; Protein crystallography data
The structure of Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug Candidate, PDB code: 4r3c
was solved by
V.L.Grum-Tokars,
G.Minasov,
S.M.Roy,
W.F.Anderson,
D.M.Watterson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4r3c:
The structure of Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug Candidate also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug Candidate
(pdb code 4r3c). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug Candidate, PDB code: 4r3c: Fluorine binding site 1 out of 1 in 4r3cGo back to Fluorine Binding Sites List in 4r3c
Fluorine binding site 1 out
of 1 in the Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug Candidate
Mono view Stereo pair view
Reference:
S.M.Roy,
V.L.Grum-Tokars,
J.P.Schavocky,
F.Saeed,
A.Staniszewski,
A.F.Teich,
O.Arancio,
A.D.Bachstetter,
S.J.Webster,
L.J.Van Eldik,
G.Minasov,
W.F.Anderson,
J.C.Pelletier,
D.M.Watterson.
Targeting Human Central Nervous System Protein Kinases: An Isoform Selective P38 Alpha Mapk Inhibitor That Attenuates Disease Progression in Alzheimer'S Disease Mouse Models. Acs Chem Neurosci 2015.
Page generated: Sun Dec 13 12:11:54 2020
PubMed: 25676389 DOI: 10.1021/ACSCHEMNEURO.5B00002 |
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