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Fluorine in PDB 4r3c: Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug Candidate
Enzymatic activity of Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug Candidate
All present enzymatic activity of Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug Candidate:
2.7.11.24;
2.7.11.24;
Protein crystallography data
The structure of Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug Candidate, PDB code: 4r3c
was solved by
V.L.Grum-Tokars,
G.Minasov,
S.M.Roy,
W.F.Anderson,
D.M.Watterson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.93 / 2.06 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 65.850, 74.512, 77.808, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 17.5 / 21.7 |
Other elements in 4r3c:
The structure of Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug Candidate also contains other interesting chemical elements:
| Chlorine | (Cl) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug Candidate
(pdb code 4r3c). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug Candidate, PDB code: 4r3c:
In total only one binding site of Fluorine was determined in the Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug Candidate, PDB code: 4r3c:
Fluorine binding site 1 out of 1 in 4r3c
Go back to
Fluorine Binding Sites List in 4r3c
Fluorine binding site 1 out
of 1 in the Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug Candidate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of P38 Alpha Map Kinase in Complex with A Novel Isoform Selective Drug Candidate within 5.0Å range:
|
Reference:
S.M.Roy,
V.L.Grum-Tokars,
J.P.Schavocky,
F.Saeed,
A.Staniszewski,
A.F.Teich,
O.Arancio,
A.D.Bachstetter,
S.J.Webster,
L.J.Van Eldik,
G.Minasov,
W.F.Anderson,
J.C.Pelletier,
D.M.Watterson.
Targeting Human Central Nervous System Protein Kinases: An Isoform Selective P38 Alpha Mapk Inhibitor That Attenuates Disease Progression in Alzheimer'S Disease Mouse Models. Acs Chem Neurosci 2015.
PubMed: 25676389
DOI: 10.1021/ACSCHEMNEURO.5B00002
Page generated: Thu Aug 1 05:30:54 2024
PubMed: 25676389
DOI: 10.1021/ACSCHEMNEURO.5B00002
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