|
Fluorine in PDB 6p5v: Structure of DCN1 Bound to N-((4S,5S)-7-Ethyl-4-(4-Fluorophenyl)-3- Methyl-6-Oxo-1-Phenyl-4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-B]Pyridin-5- Yl)-3-MethylbenzamideEnzymatic activity of Structure of DCN1 Bound to N-((4S,5S)-7-Ethyl-4-(4-Fluorophenyl)-3- Methyl-6-Oxo-1-Phenyl-4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-B]Pyridin-5- Yl)-3-Methylbenzamide
All present enzymatic activity of Structure of DCN1 Bound to N-((4S,5S)-7-Ethyl-4-(4-Fluorophenyl)-3- Methyl-6-Oxo-1-Phenyl-4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-B]Pyridin-5- Yl)-3-Methylbenzamide:
3.2.1.17; Protein crystallography data
The structure of Structure of DCN1 Bound to N-((4S,5S)-7-Ethyl-4-(4-Fluorophenyl)-3- Methyl-6-Oxo-1-Phenyl-4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-B]Pyridin-5- Yl)-3-Methylbenzamide, PDB code: 6p5v
was solved by
R.K.Guy,
H.S.Kim,
J.T.Hammill,
D.C.Scott,
B.A.Schulman,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of DCN1 Bound to N-((4S,5S)-7-Ethyl-4-(4-Fluorophenyl)-3- Methyl-6-Oxo-1-Phenyl-4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-B]Pyridin-5- Yl)-3-Methylbenzamide
(pdb code 6p5v). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of DCN1 Bound to N-((4S,5S)-7-Ethyl-4-(4-Fluorophenyl)-3- Methyl-6-Oxo-1-Phenyl-4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-B]Pyridin-5- Yl)-3-Methylbenzamide, PDB code: 6p5v: Fluorine binding site 1 out of 1 in 6p5vGo back to Fluorine Binding Sites List in 6p5v
Fluorine binding site 1 out
of 1 in the Structure of DCN1 Bound to N-((4S,5S)-7-Ethyl-4-(4-Fluorophenyl)-3- Methyl-6-Oxo-1-Phenyl-4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-B]Pyridin-5- Yl)-3-Methylbenzamide
Mono view Stereo pair view
Reference:
H.S.Kim,
J.T.Hammill,
D.C.Scott,
Y.Chen,
J.Min,
J.Rector,
B.Singh,
B.A.Schulman,
R.K.Guy.
Discovery of Novel Pyrazolo-Pyridone DCN1 Inhibitors Controlling Cullin Neddylation. J.Med.Chem. V. 62 8429 2019.
Page generated: Sun Dec 13 13:05:03 2020
ISSN: ISSN 0022-2623 PubMed: 31465221 DOI: 10.1021/ACS.JMEDCHEM.9B00410 |
Last articlesZn in 8WB0Zn in 8WAX Zn in 8WAU Zn in 8WAZ Zn in 8WAY Zn in 8WAV Zn in 8WAW Zn in 8WAT Zn in 8W7M Zn in 8WD3 |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |