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Fluorine in PDB 6el7: Glucocorticoid Receptor in Complex with Compound 31Protein crystallography data
The structure of Glucocorticoid Receptor in Complex with Compound 31, PDB code: 6el7
was solved by
K.Edman,
L.Wissler,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6el7:
The structure of Glucocorticoid Receptor in Complex with Compound 31 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Glucocorticoid Receptor in Complex with Compound 31
(pdb code 6el7). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Glucocorticoid Receptor in Complex with Compound 31, PDB code: 6el7: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 6el7Go back to Fluorine Binding Sites List in 6el7
Fluorine binding site 1 out
of 2 in the Glucocorticoid Receptor in Complex with Compound 31
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 6el7Go back to Fluorine Binding Sites List in 6el7
Fluorine binding site 2 out
of 2 in the Glucocorticoid Receptor in Complex with Compound 31
Mono view Stereo pair view
Reference:
L.Ripa,
K.Edman,
M.Dearman,
G.Edenro,
R.Hendrickx,
V.Ullah,
H.F.Chang,
M.Lepisto,
D.Chapman,
S.Geschwindner,
L.Wissler,
P.Svanberg,
K.Lawitz,
J.Malmberg,
A.Nikitidis,
R.I.Olsson,
J.Bird,
A.Llinas,
T.Hegelund-Myrback,
M.Berger,
P.Thorne,
R.Harrison,
C.Kohler,
T.Drmota.
Discovery of A Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile. J. Med. Chem. V. 61 1785 2018.
Page generated: Sun Dec 13 12:49:33 2020
ISSN: ISSN 1520-4804 PubMed: 29424542 DOI: 10.1021/ACS.JMEDCHEM.7B01690 |
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