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Fluorine in PDB 6q6f: Crystal Structure of IDH1 R132H in Complex with HMS101Enzymatic activity of Crystal Structure of IDH1 R132H in Complex with HMS101
All present enzymatic activity of Crystal Structure of IDH1 R132H in Complex with HMS101:
1.1.1.42; Protein crystallography data
The structure of Crystal Structure of IDH1 R132H in Complex with HMS101, PDB code: 6q6f
was solved by
A.Chaturvedi,
R.Goparaju,
C.Gupta,
T.Kluenemann,
M.M.Araujo Cruz,
A.Kloos,
K.Goerlich,
R.Schottmann,
E.A.Struys,
A.Ganser,
M.Preller,
M.Heuser,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of IDH1 R132H in Complex with HMS101
(pdb code 6q6f). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of IDH1 R132H in Complex with HMS101, PDB code: 6q6f: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 6q6fGo back to Fluorine Binding Sites List in 6q6f
Fluorine binding site 1 out
of 2 in the Crystal Structure of IDH1 R132H in Complex with HMS101
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 6q6fGo back to Fluorine Binding Sites List in 6q6f
Fluorine binding site 2 out
of 2 in the Crystal Structure of IDH1 R132H in Complex with HMS101
Mono view Stereo pair view
Reference:
A.Chaturvedi,
R.Goparaju,
C.Gupta,
J.Weder,
T.Klunemann,
M.M.Araujo Cruz,
A.Kloos,
K.Goerlich,
R.Schottmann,
B.Othman,
E.A.Struys,
H.Bahre,
D.Grote-Koska,
K.Brand,
A.Ganser,
M.Preller,
M.Heuser.
In Vivo Efficacy of Mutant IDH1 Inhibitor Hms-101 and Structural Resolution of Distinct Binding Site. Leukemia 2019.
Page generated: Sun Dec 13 13:07:41 2020
ISSN: ESSN 1476-5551 PubMed: 31586149 DOI: 10.1038/S41375-019-0582-X |
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